ID A0A3P8UPR7_CYNSE Unreviewed; 680 AA.
AC A0A3P8UPR7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=X-prolyl aminopeptidase 2 {ECO:0000313|Ensembl:ENSCSEP00000004352.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000004352.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000004352.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000004352.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR RefSeq; XP_008324639.1; XM_008326417.2.
DR AlphaFoldDB; A0A3P8UPR7; -.
DR STRING; 244447.ENSCSEP00000004352; -.
DR Ensembl; ENSCSET00000004407.1; ENSCSEP00000004352.1; ENSCSEG00000002827.1.
DR GeneID; 103390529; -.
DR KEGG; csem:103390529; -.
DR CTD; 7512; -.
DR GeneTree; ENSGT00940000157196; -.
DR InParanoid; A0A3P8UPR7; -.
DR OMA; LVDQAWG; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000265120; Chromosome 15.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF4; XAA-PRO AMINOPEPTIDASE 2; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..680
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017991109"
FT DOMAIN 54..185
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 365..575
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 586..649
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 680 AA; 76563 MW; 6B375F94E9403F6D CRC64;
MRSYGWTGAL VLVLVLTLSN LTGKSAAVDG ATERNCSLSP PYIPSTAVNS SVQLKELRQK
MLPLNISAYI IPGTDAHLSE YIAPRDSRLT FMTGFTGSAG TAVVTRSKAA LWTDSRYWLQ
AERQLDCNWE LQQSYSVGNI AEWLIAQVPL GEVIGFDPFL FSLQTQENYM LNLMSSNRSL
APVSENLVDQ VWKDRPAVSP ENLIRLPDRV ILRSWQTKVE LIRSQMRDNP YKPTALLLSA
LDETAWLFNL RGNDIPYNPF FYSYTLLTLD QIWLFVHTHR VTEELRRYLN ASCVDSLCVQ
LKSYDSVSEN IESYVSQIGV KVWIGTEYTN YALYQLITPQ DKLLTSSYSP VLMTKAVKDE
TEQRILREAH VRDAVAVMQL LLWLEKSVPG GKETELTAAN YVNTCRSKQN DNRGPSFETI
SASGPNAALA HYSPTNETDR KLTPTEMFLL DSGGQYLDGT TDITRTVHWG VPTALQKEAF
TRVLMGNIEI SRTVFPTRTR GVNIEMLGRR ALWEVGLNYG HGTGHGVGNY FGVHEWPVGF
QSNNIPFTAG MFTSIEPGYY KENDFGIRIE DVAVIVPYQT QYGNHFLTFD TVSLVPYDRK
LIDVSLLSAE QIQWLNNYYQ KIRTVVGPEL DKQGLSEENE WMLRNTEPFP APGSSSSNCS
SSLTLLLLAL AFTLHHSRII
//
