ID A0A3P8UQH8_CYNSE Unreviewed; 262 AA.
AC A0A3P8UQH8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Stanniocalcin {ECO:0000256|ARBA:ARBA00017831, ECO:0000256|RuleBase:RU369112};
DE Short=STC {ECO:0000256|RuleBase:RU369112};
DE AltName: Full=Corpuscles of Stannius protein {ECO:0000256|RuleBase:RU369112};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000002500.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000002500.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000002500.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Its primary function is the prevention of hypercalcemia. Upon
CC release into the circulation, it lowers calcium transport by the gills,
CC thereby reducing its rate of influx from the environment into the
CC extracellular compartment. STC also stimulates phosphate reabsorption
CC by renal proximal tubules. The consequence of this action is increased
CC levels of plasma phosphate, which combines with excess calcium and
CC promotes its disposal into bone and scales.
CC {ECO:0000256|ARBA:ARBA00003962, ECO:0000256|RuleBase:RU369112}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748,
CC ECO:0000256|RuleBase:RU369112}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU369112}.
CC -!- SIMILARITY: Belongs to the stanniocalcin family.
CC {ECO:0000256|ARBA:ARBA00008693, ECO:0000256|RuleBase:RU369112}.
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DR RefSeq; XP_008322955.1; XM_008324733.1.
DR AlphaFoldDB; A0A3P8UQH8; -.
DR Ensembl; ENSCSET00000002540.1; ENSCSEP00000002500.1; ENSCSEG00000001669.1.
DR GeneID; 103389349; -.
DR KEGG; csem:103389349; -.
DR CTD; 393511; -.
DR GeneTree; ENSGT00390000005989; -.
DR InParanoid; A0A3P8UQH8; -.
DR OMA; IFQTMIA; -.
DR OrthoDB; 4573585at2759; -.
DR Proteomes; UP000265120; Chromosome 14.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0034765; P:regulation of monoatomic ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR InterPro; IPR004978; Stanniocalcin.
DR PANTHER; PTHR11245; STANNIOCALCIN; 1.
DR PANTHER; PTHR11245:SF7; STANNIOCALCIN; 1.
DR Pfam; PF03298; Stanniocalcin; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|RuleBase:RU369112};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Secreted {ECO:0000256|RuleBase:RU369112}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..262
FT /note="Stanniocalcin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018035223"
SQ SEQUENCE 262 AA; 29043 MW; D458BF3FB0660052 CRC64;
MLPPGSSCFL LLLVLPSILS FTVQMLPEEA APRRARFSSN SPADVARCLK SSVGVGCGFF
SCLENSTCDT DGMHEICELF LHTAATFNTE GKTFVKKSLQ CVSQAIAAKV QHTIRRCNIF
QRMIAEVQEE CYTRFDICTV ARTNPDAIGE VVQMPTHFPN RYYSTLLQTL QSCDDQTVAA
VRAGVVARLG PDMETFLQLV QNKPCSSGSP VPASVYNNPA SWRNMPVFNV QPSFIGRDDT
HLFARRSVDE QMQDQVQTES EK
//
