ID A0A3P8UQU9_CYNSE Unreviewed; 421 AA.
AC A0A3P8UQU9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=GDNF family receptor alpha-4-like {ECO:0000313|Ensembl:ENSCSEP00000004727.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000004727.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000004727.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000004727.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961}.
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DR AlphaFoldDB; A0A3P8UQU9; -.
DR Ensembl; ENSCSET00000004784.1; ENSCSEP00000004727.1; ENSCSEG00000003056.1.
DR GeneTree; ENSGT00940000160491; -.
DR OMA; GTDCLVA; -.
DR Proteomes; UP000265120; Chromosome 15.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR PANTHER; PTHR10269:SF2; GDNF FAMILY RECEPTOR ALPHA-4; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 3.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; GDNF receptor-like; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..421
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018100026"
FT DOMAIN 29..108
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 148..228
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 238..332
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT REGION 344..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 46228 MW; 8E203A1C4219ADD5 CRC64;
MVSYTHTSVC FFLGLFYFYL TAILAGSDCL VAGDLCSSDE VCSPRLRTLR QCVAGDGSMK
LGPGAKSQCS NAVSALMSSP LHGCQCRRGM KMEKNCLSIY WSLHQAFIHG LNLVEPFPYE
TVLRDYEYVR LASITADLDV GMTNVNRCLD AAKACNVDDV CQKLRTEYVS ACIKPTSKSG
PCNRPKCNKA LRRFFDRVPA DYTHELLFCP CTDTACAERR RQTIVPSCSY EGPEKPSCIS
QIRMCKSDYV CRSRLAQFQY DCEPSETAVS GCKQGNYAAC LLAYTGLIGS TITPNYVDNS
TSSVAPWCSC SSSGSQRQEC DHFLGTFTDN ICLRNALLKF GSESEQQPTL GQTNVPRSTS
RTTITTSITS TENRRATSSP PETKETPNNV IDAFIPTQVR GGNQQHDKGR HSALTAFLTC
G
//
