ID A0A3P8URJ4_CYNSE Unreviewed; 1138 AA.
AC A0A3P8URJ4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Desmoglein-3-like {ECO:0000313|Ensembl:ENSCSEP00000003326.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000003326.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000003326.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000003326.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of intercellular desmosome junctions. Involved in
CC the interaction of plaque proteins and intermediate filaments mediating
CC cell-cell adhesion. {ECO:0000256|RuleBase:RU004358}.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; A0A3P8URJ4; -.
DR STRING; 244447.ENSCSEP00000003326; -.
DR Ensembl; ENSCSET00000003371.1; ENSCSEP00000003326.1; ENSCSEG00000002167.1.
DR GeneTree; ENSGT01030000234624; -.
DR InParanoid; A0A3P8URJ4; -.
DR OMA; PEPMIHG; -.
DR Proteomes; UP000265120; Chromosome 2.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 4.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR009122; Desmosomal_cadherin.
DR PANTHER; PTHR24025:SF23; CADHERIN-4; 1.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 2.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01818; DESMOCADHERN.
DR SMART; SM00112; CA; 3.
DR SUPFAM; SSF49313; Cadherin-like; 4.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 560..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..125
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 190..335
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 336..447
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 946..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1138 AA; 123670 MW; 26D5C731F3A1359F CRC64;
MLSAKGQEME AKSRKKREWI LPPAKLMENT DYTHKEFIAK IRSDNEEKGK VEYYLSGPGA
NKPPINLFLV DHDTGFVTIT DILDREKYLS YNLTGVAKYR DGTFAEENVP LTVIVLDQND
NAPYFELHTG SITEASKPEI DCWTCELCGQ TNSQLFTHFF HSFNGQSRSW TQSQLTKGKL
HLNLSFVALS RYTYYSRVVD ENVADVVVMK IKALDDDLVN TDNWLAVFTI AKGNEDNLFS
IETDKETNEG ILKLIKAVDF ENVKNIELRI LVGEGGPLGV GTGVGAGVGA GVGAGADLSA
EVGVDLSAEV GVDLSGEAGV EGGISVNNLP EDPAFVPETK VVPVSEDPSD SPKDGVITTY
AAVDPDTGEP SEDVNYAKAY DPGNWFTVDE ETAEIKLNKA PDRESPFLVN GTYIAKILAI
SKDMPAKTAT GTLAIKVMDS NDHCPTLTTS HNSLCDNQKT VIVTGHDVDA NPNAAPFSFK
IVPEGTRGSW TVGQINETSA LIQSEESLWP GFYELQLEVF DAQGLSCPEK EVFTVEVCTC
VETDHCGPRK ERQTATSSKL SVPAISLLFM ALCLLLFIPF LLLFCECGGK GKIFSDHFKE
IPFDNKQHLI SYHTEGIGED KVGLSDTFFP ILQEVPLQSV PIMLGGQNNV DGGQTLNKNQ
QQQTIREFGT VENHQTFYND TIQKIWEGSQ SLLETDYLDY NHKTGLLRQR LGNTKGIFEN
MALPDTYLHD YFSQKAVLAE AVKDDLLDFN YEGQGSPAGS VGCCSLLESD NDLQFLNDLG
TKFKILADIC LPPTPKSTTT FKEVLPSEPV FKSQTKHTVD MKNMNTRVEN EVTTVDTPKL
PPTQHSSTTL SQTNVTNFSH SANINHSANI NHSSNVHHSS TLPSMPIQTV VLQQQPMYYT
TNSVLQPVQY VVNPQLQSTV LLADGTPGSN YQGLYVVSGA HSPPGINLPK KSSSGLLSKG
VESPQSPGSP TNVGSPKQLV PGGPSVDGWK VVGPNPDGNY TIVKQKKKKR SASFKGSSPK
DAVLVKEAAS PQGTLVTAAL GSVSGILPRH TVVQDGNVIT LNQTGQTWVG LPEPMGLGPM
TALGVGVEQQ SVASVGTVGV NQFHKVSLEK REIRAVESTS IPHYQGTGKT VKVRELKI
//
