ID A0A3P8URY7_CYNSE Unreviewed; 1037 AA.
AC A0A3P8URY7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Diaphanous-related formin 2 {ECO:0000313|Ensembl:ENSCSEP00000003015.1};
GN Name=DIAPH2 {ECO:0000313|Ensembl:ENSCSEP00000003015.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000003015.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000003015.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000003015.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR AlphaFoldDB; A0A3P8URY7; -.
DR Ensembl; ENSCSET00000003059.1; ENSCSEP00000003015.1; ENSCSEG00000001949.1.
DR GeneTree; ENSGT00940000157822; -.
DR OMA; FHHCIES; -.
DR Proteomes; UP000265120; Chromosome 15.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF3; PROTEIN DIAPHANOUS HOMOLOG 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 71..435
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 614..1014
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 482..509
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 895..922
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..598
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1037 AA; 117699 MW; 9EF54D42F89725CE CRC64;
MDQASGGEDP NKPSKKKSGD DEGKNKKLRD RITSFRKAGM KKEKPLIQHP TDPLSTQAEL
PVPQLFFDDR STNLSEKEII DLFEKMMEDM NLNEDRKAPL RGKDLSTKRE MVVQYISATA
KSGGLRNSKH ESTLSSQEYV HELRSGITEE KLLNCLESLR VSLTSNPVSW VNNFGHEGLG
LLLDSLEKLL DKKHQETIDK RNQHKLIQCL KAFMNNKYGL QRILGDERSL LLLARAIDPK
QTHMMTEIVK ILSAFCIIGE ENILDKILAA MTVTAEKNNK ERFSCIVEGL ENHEAQQLQV
ACMQLINALV TSPDDLDFRI HLRNEFLRCG LRKILPELKE TEELDIQLKV FNENKEEDAI
ELSHRLDDIR AEMDDMGEVF HLLSNMVRDT GSETYLLSIL QHLLLIRNDY YIRPQYYKVI
EECVSQVVLH RSGMDPDFGY SRRLDVDFTH LIDQCVDKAK VEESEQKASE FSKKFDEEFS
ARQEAQAEAQ KKDERIKELE GKIQTLETQV AAGVKAPGAP TAPGGAAAPP PPPPPPPPPP
PPGAGPPPPP PLPGHAGIPP PPPPPPPPGG GPPPPPPPPG CGPPPPPPPF FGGPGAPPPP
PMLPVVKLPY GLEPKKAYKP ETVMKRVNWT KIVPQEMSEN CFWIKVKEEK FENPDLFAQL
SLCFSSHSKA KKDVKDETDN RMAQIKKKTK ELRILDPKTA QNLSIFLGSF RLPYEEIRDI
VLEVDEERLS ESLIQNLIKN LPEQKELSAL AELKGEYEEL VESEQFSVVM SSVKLLRPRL
NGILFKLTFE EQVNNIRPDI MNVTFACEEL KKSENFTKFL ELVLLVGNYM NAGSRNAQTF
GFNLSFLCKL RDTKSIGQST TLLHFLAEKC QDNYPSLLGF PDELEHVEDA SRVSAEILKG
SLSTMERQIQ RLENDIENFP KKDDQQDKFV EKMSGFSKHA REQYEKLSTM HKNMQKLYES
LGSYFAFDPH TVSLEEFFGE LANFRMLFLE AVKENHKKRE MEEKIKRAKL AKEKAEREKQ
ERQQKKKQLI DMNKAAR
//