ID A0A3P8USJ7_CYNSE Unreviewed; 475 AA.
AC A0A3P8USJ7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=XK-related protein {ECO:0000256|RuleBase:RU910716};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000006178.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000006178.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000006178.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU910716}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU910716}.
CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000256|ARBA:ARBA00008789,
CC ECO:0000256|RuleBase:RU910716}.
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DR RefSeq; XP_008326241.1; XM_008328019.2.
DR AlphaFoldDB; A0A3P8USJ7; -.
DR STRING; 244447.ENSCSEP00000006178; -.
DR Ensembl; ENSCSET00000006247.1; ENSCSEP00000006178.1; ENSCSEG00000003969.1.
DR GeneID; 103391664; -.
DR KEGG; csem:103391664; -.
DR CTD; 7504; -.
DR GeneTree; ENSGT00390000003231; -.
DR InParanoid; A0A3P8USJ7; -.
DR OMA; SGGDGMW; -.
DR OrthoDB; 5265454at2759; -.
DR Proteomes; UP000265120; Chromosome 16.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018629; XK-rel.
DR PANTHER; PTHR14297:SF8; ENDOPLASMIC RETICULUM MEMBRANE ADAPTER PROTEIN XK; 1.
DR PANTHER; PTHR14297; MEMBRANE TRANSPORT PROTEIN XK FAMILY MEMBER; 1.
DR Pfam; PF09815; XK-related; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU910716};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU910716};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU910716}.
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 166..185
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 206..229
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 235..256
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 277..298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 350..372
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT REGION 401..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 53679 MW; 78429EF55FDAECD1 CRC64;
MRLPISIFVS VSLFTAETTA ALYLSSTYRS AGDRIWQALT LLFTLVPSVL VQLTLTFIHR
DLGRDRPLVL LLHILQLGPI VRCLEAFCIY GSVGRVEEPY VSITRKKQMP RGGQSEEVEL
QVGQAEGKLF THRAAFARTS VIQAFLGSAP QLTLQLYICA LQQGVSIGRG TLMVISLLSI
VYGALRCNIL AIKLKYDDYE VDIRPMAYVC IFLWRSFEIA PRVVVLVLFS SVLQLWVLPV
VLLNFLVFFF YPWILFWHSH SPFPENIEKT LSSVGTTIVL CMLTFLYAGI NMFCWSAVQV
KLNDPDLINK SQNWYRMAVY YMLRFVENAS LLLLWFIYKT NIYDFIYAPM LVLQLLLAYA
IAIFFMLVFY QFCHPCRKLF SSSMSQGLWN CSSLLCLTCS SSPSPTRSKR KTTPEPPQPS
RRADAAAADD TGSDHMEDGP NDTTYDVLSD TIYDIPNETV STNNGDVSTS LTCNV
//
