ID A0A3P8USP2_CYNSE Unreviewed; 4596 AA.
AC A0A3P8USP2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=FAT atypical cadherin 3a {ECO:0000313|Ensembl:ENSCSEP00000004849.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000004849.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000004849.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000004849.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 244447.ENSCSEP00000004849; -.
DR Ensembl; ENSCSET00000004905.1; ENSCSEP00000004849.1; ENSCSEG00000003138.1.
DR GeneTree; ENSGT00940000154981; -.
DR InParanoid; A0A3P8USP2; -.
DR OMA; HFLMDSN; -.
DR Proteomes; UP000265120; Chromosome 4.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0060536; P:cartilage morphogenesis; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 34.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF422; NEURAL-CADHERIN 2-RELATED; 1.
DR Pfam; PF00028; Cadherin; 28.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 34.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 15.
DR PROSITE; PS50268; CADHERIN_2; 32.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..4596
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017988440"
FT TRANSMEM 4189..4209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..165
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 166..273
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 382..477
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 478..583
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 592..686
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 732..836
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 838..942
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 943..1049
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1058..1154
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1155..1263
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1276..1375
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1381..1478
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1479..1584
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1585..1689
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1690..1787
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1788..1901
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1902..2000
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2001..2102
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2103..2204
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2205..2305
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2306..2412
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2413..2514
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2515..2618
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2619..2726
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2727..2837
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2838..2951
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2952..3056
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3057..3158
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3159..3261
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3262..3366
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3367..3470
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3471..3575
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3819..3857
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3859..4048
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4051..4088
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4090..4126
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4128..4168
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1354..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4407..4429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4441..4596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4469..4486
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4487..4509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4535..4557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4568..4582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 4078..4087
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4116..4125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4158..4167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4596 AA; 503815 MW; 7CC1E1ED944FF239 CRC64;
MDVNMGQWAG MRAPFYSLAL LLPLLLLTSP LCCSQSTQGG PQDGPHFGFT QAVYRATVYE
NSAARTYANS KIKMGIHLAQ RSWDVRYRIT SGDDEGLFKA EEFVLGDFCF LRIRTKGGNA
AILNREIQDN YVLTVKASVK GEAFLETWTK VSIQVLDMND LRPLFSPTTY SVTIAESTPL
RTSIAQVTAT DADIGSNGEF YYFFKEKMEL FAVHPTSGVV SLSGKLNVDE QSRYDLEILA
VDRGMKLYGN NGVSSTAKLF VHVERVNEHA PVMNVVTLSP SWLDKNPVYA VVTVTDLDEG
INGEIDSVDI VGGDPLEQFF IEMSEEEEFA IKASESLNWD LYPYGCNLTL QAKDKGAPQK
FSTVRLVHII VKRPHTEEVK FEQEVYEVSL NEISPPGTVV EAVKIKPEPD DAEYILTPSA
DSAFFQMNTL TGVVSTKRWF TQVTQNVFNL EVMESDSELR VKVRVTIEDA NDNTPTFAQS
SYEIFVNESV PVGTSVLTVS AVDEDLGENG YITYSISSLH LLPFRINQFS GVISTTKELD
FESSPESFVF VVRASDWGSP YRRESEVNVT IHLENVNDNQ PLFENVACQG VISRDFPVDE
VITTMSAIDV DELELVKYKI ISGNELGYFD LNPDSGVLAL QHSLATANPK NNVFSLKITA
TDGENFSDPM FVNISIVHGK SPPKGFTCKE TKVAQKLAEK LLKKSKASTK PKIEEGFIDL
FSVNRQTPQF DKAFPTDISV REDLQVGSSV FQVNAFDGDT GFNGHILYAI SDGNIDSCFT
INMETGLVSV FLPMDREKRD RYLLNLTIFD LGLPQKTAWR LLTVYIEDAN DNAPQFLQEG
GYKILLPENT AIGTDVIQVE ATDKDLGANG DVTYSILTST TQFSINSTNG IVYVAGQLDR
EFVSTFNLKI EARDKADRGS QKFSTTTLKI ILEDVNDCPP LFIPSVYKAK ALEDLPVGTV
VAWLETLDPD LGLGGQVRYS LANDYNGWFE VDKASGAIRL TKELDYETQQ FYNLTVKAKD
KGRPVSLLSV TFVEVEVVDV NENLYTPYFS HFALSGLVKE NARIGTTLLQ VTANDDDSGR
DGEIQYSIRD GSGLGRFAID EETGVIYTTD MLDRETKDSY WLTVYASDHG VVPQFATIEV
FIQVEDVNDN APLTSEPMYR PSVTENSPRD VSVIQIQAQD PDTTPPAAGE KLNYRIISGN
PQNFFTINSR TGLITTTSRK LDREQQAEHV LEVLVSDGGP SPRQTTVWVM VQVLDENDNK
PTFPEKVYQV KLAERERRKK GEPIYRVFAY DRDEGPNGDL SYSIVDGNEE GKFFIDPKTA
VVSSRKAFSA GSYDILTIKA TDNGRPQKSA TARLHITGPG RGRGGAGPPP PPPAALPLLF
DESFYNFTVM ENDKVAEIVG VVTLQQTDAP LWFDIAGGNS DSVFDIEKAV GTIIIARPLD
AEQRSFYNLT VQATDGTTTA FTQVHITVLD NNDNPPVFSQ STYDVTISED TPPDTEVVQV
LASDRDEHHR LTYSLQSSID PNSMRLFRID PNVGTIYTVQ RLDHEACAQH ILTVIVKDQE
FPYRKNLARV LIEVEDINDH VPIFTSALYE GQVYESAAVG SAVVQVTALD KDKGANAELH
YSIEAGNTGN AFSIEPVLGL ITVARDLDLS NIGHYVLTVR VTDNGAPPLS TTTVVRVAVT
LSDNAGPKFP QPEYQAEISE KAMIGTSVTT VMAVSQSTLT YDIKKGNTDR VFQINQYSGV
ITTQNLLDFE TTSSYTLIIR ASNMAGMSSN VTVVIQVVDE NDNPPVFQLL HYLGRISEAA
PVNSVVLDSG DSPLVIRATD ADRNQNALLV YQIVEDTAKM FFTVDSGTGS IRTIANLDHE
TFATFHFHVH VRDNGRPQLT AESPTEVTIQ VIDTNDSPPH FTQNAYETVL LLPTYVGVEV
LQVSAVDPDK DVPSELTYTL TDGALEYFAI KPSSGVIVVK NNNLSKERFR FNVKVSDGKF
SSMALVTILV REALDSGLSF SQSLYSSSIQ ENVSNITKVA VVNAVGNRLN EPLKYTLLNA
GTRFRIRPTS GVIQTTGIPF DREEQEFYEL VVEAKREHDR LHVARVMVRV QIEDINDNAP
VFVGLPYYAA VQVEAEPGSP IFRVMAIDSD KGLNGEVSYY LMDDHGHFEI SRQTGHLTLK
RSFDSDLSNV EYQMVIYAKD GGYPPLSSTI EFTITVVNKA MPVFDKSFYS VAVNEDVSVH
TPILSINASS PEGQNIIYTI VEGDPSLQFD VGFDTGVISV IHALDYEAAS SYHLTVRATD
YLTSARAEVD VEVIVLDVND NPPVFQKMSY TVVLSETAMI GTPALQVIAT DRDSEKNNIV
RYQLFSDAHN STDYFHIDSS SGLILTARML DHELLQRYDF IVKATDNGFP PLSSEVSVKV
MVNDMNDNPP VFNQLLYESY VNELAPRGHF VTCVQASDAD SSDFDHLEYG ILSGNEKMNF
LMNKKTGIIT LSGHRKQRME SVHSLNVSVS DGVFTSTAQV HVKVLEANLY SPVFGQNMYE
AELRENAAVG TKVLQVKATD ADPGTYGHIT YSFVNDVGKD QFSIDSIGQI STLEKLDRED
PANKDIVLTV GARDSGGRAS YCTVHITLLD DNDNVPRFHA TEYRASVKSD VAKGFLVTQI
QAQDPDDGTN AKVKYSLYSE AHVPVVDILE IDPDNGWMVT KGSFSHLRNS VLSFFVKAVD
GGNPVRHSLV SVYIHVLSPE SSIPHFSQHQ YLFSVPEDLP IGSAIGTVRL NTPPGHEPLS
ATFALVNGET KENNQDGVLV VDKSTGVIKL DKPLDYEVVK GFHFKVTATL QQAKLDSVST
VDVEVRVLDL NDNKPAFETN SYEATIMEGM SIGTRIIQVQ AVDPDAGANG QVTYSLGALT
QSAGDAETLG RTFSIDSNTG WISTRKDLDH ETHPSYTFTV VASDLGETLS LSSTTTVTVV
VSDVNDNPPR FVEQHYFGSV QESDPPGEVV AVLNTRDDDS SAVNRQVSYH ITGGNYRGVF
ALGLVQGEWK MYVKGLLDRE ERNLYIINVT ASDGLFVSQA TVEITVMDAN DNSPVCDQAV
YTASVPEDLP VNSVVLRVGA TDADMGLSAW IQYSLHGPGS QHFSLDSDTG VIKSSVSLDR
ETTPRYQLVA QATDGGGRWC RAEVQLIVTD VNDNPPIFTL SQYTASVYED TAIKALLTRI
QAIDPDEGRV VVYSMADSAG GTFSIDKSSG IMVLESVLDR EVQPAYQVTV RASDQGSPSP
LSSLVNVTIT VLDINDNPPV FERRDQLATV PEDVSMGTEV LRVYAASKDI GTNAEITYSI
RSGNEHGKFY IHPLTGVILV ALPLDYETCK DYFLTVEARD GGTPPLSAIT TVNINLTDVN
DNAPVFSRDL YAAVVSEDAT IGDSVVQLVA EDVDSQVNGD ILYSIVSGDR DNQFFIDPLS
GVIKVNKQLD REKVSYSLSI RALDSGAPPL SSTVMVNIDI SDINDNPPTF SPANLTTVIQ
ENKPVGTTIL QLSVVDLDSS HNGPPFDFHI LSGNEGGEFV LENDGTLVAN RVFKRNLVTE
YVLQIQVTDS GKPRLSSSST LTVRVIEESL HRPVALPLEV HIITMEDEFP GGVIGQLHAT
DADPYDALTF GHAPPAHRSL FKISPRDGKI IALGGLDAGR YSLNASVSDG RFAVPVPVSV
HVEQATPEML REAVTVRFES VSPQDFVASH LKSVLKVLQH AATSQGQDTL HLLSLQPVGG
TQQLDLLVAV ETVGGGYYKA AYLTQKLSAS RRQLEEVLRV SAILDKNCSG LECRGAQCEQ
TIVLDSHNLA TYSTPRVSFV SPRFQRTSRC TCNGERLRGW RWCEDQSCPA DMQCVSVEAT
RGRYACQCPP GKLGECAGHS SLSFSGNSYI KYRLSDRLQT ELKLSLRIRT LQSRGIIMYT
HTEPCTVLKL EDGKLWLQLA CGLGSGVGDS PNMLGISGRR ISDGSWHTVA LELNRNFSSL
ALDDSYVEQR RGPPFMQPLA PDRTIFFGAL VQPANSRSLM DPQKDPRVLE GFQGCLDSVM
LNNNELPLQN KRTHYAEVVG LTDLKLGCVL YPDACLQQPC RNGATCTSLP SGGFSCSCYP
QFTGGRCEVE ITACVPNPCH NGGICKPIGN AFLCSCRRGF KGLTCEEDVN ECDRSNPEGE
CENGGVCINT HGSFYCNCTA GFVGQRCGLR PVVVPNMQAG HTVVGKEELI GIAVVLFVIV
TLIILFIAFR KKVFQKNYSR NNLSLVQDPA TAALLNKANG VQFKTLHCSP GDPLNLYAEP
VLTGGGMMGP PQVPVRPMAY TPCFQGDPRS TLEKMVDGRS VEHTEMSTFH SESPRILSGT
TRRGVVVCSV APNLPPVSPC RSDCDSIHKS PWDSDEGECV TCFSGSNKGS NSEVQSLNSF
QSDSCDDNAY HWDTSDWMPS TRLSDIEEVP GYETGPPPEV ARSVSRLGGS TRELESDYYL
GGYDIDSDYP PPHEEEFLTQ DQLPPPLPTG EDYSEPYSPP PTNPPVSKES TLSSGSTGRQ
HSRQHFHPSQ YLPPHQLPLG ELPHADFSAG GLTPGNGDTD DSLSINIRLS VGASSASDMS
VPGGLEDSER GSDFDSMDEL RRGVTITTES QQQTEV
//
