ID A0A3P8UT84_CYNSE Unreviewed; 557 AA.
AC A0A3P8UT84;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=SH2 domain containing 3A {ECO:0008006|Google:ProtNLM};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000003911.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000003911.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000003911.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8UT84; -.
DR Ensembl; ENSCSET00000003960.1; ENSCSEP00000003911.1; ENSCSEG00000002449.1.
DR GeneTree; ENSGT00940000154130; -.
DR Proteomes; UP000265120; Chromosome 9.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF11; SH2 DOMAIN-CONTAINING PROTEIN 3A; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 69..169
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 286..549
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 557 AA; 62190 MW; 3E30734FDFA558B8 CRC64;
FYTAVSLGVR LRERRVSRKY SLGSSLDLVR PGPEPYPTLF GGRREMDLLK KELEEEMKLG
TDDPRSHAWY HGPLPREVAA ETLFERDGDF LVRDSSSSSG DYVLSCYWMN GPMHFKIIRV
VLRPKKGYTR ELFQFEEDRF DNVPALIRYY VGGRRPISQA SGAVIFHPIT RTLPLRVIAE
QHAGSSKAGG EKNGAPNKRR SLCSTHTDSL LCVNPLLRCV CVGSQPANME HVGRGPPLQS
AQSDSNLRTG SCFQLDQFES LLLPENNRPL DPSILLALKE LFNRSDANTT ALHVLSVDCQ
VARVVGVSEE QKRLMGVGSG LELVTLPHGH QLRQDLLERH HLLALGVAVD VLGCTGTVSQ
RATVLHKFIL LAQALKDHAH DLYSFSAVMK ALDMSQVVRL QMTWRALRRN HTESAVLYEK
KLKPFMNSLN EGDESVVQGP VAVPHLIPLL MLMEGEDPVE NSDRGCQLLY DLLQSARSIA
VHAEDYQSHA HSLLSGDHRP TSTPLLEACR TEFALRLLWG HAGATASRNE RYEKFDKILC
VLSDKLEPVK HSPLPPT
//
