ID A0A3P8UTG8_CYNSE Unreviewed; 1061 AA.
AC A0A3P8UTG8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRID1 {ECO:0000313|Ensembl:ENSCSEP00000005129.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000005129.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000005129.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000005129.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR RefSeq; XP_016892791.1; XM_017037302.1.
DR RefSeq; XP_016892792.1; XM_017037303.1.
DR RefSeq; XP_016892793.1; XM_017037304.1.
DR RefSeq; XP_016892794.1; XM_017037305.1.
DR AlphaFoldDB; A0A3P8UTG8; -.
DR Ensembl; ENSCSET00000005189.1; ENSCSEP00000005129.1; ENSCSEG00000003314.1.
DR GeneID; 103387089; -.
DR CTD; 793756; -.
DR GeneTree; ENSGT00940000155910; -.
DR InParanoid; A0A3P8UTG8; -.
DR OrthoDB; 511851at2759; -.
DR Proteomes; UP000265120; Chromosome 12.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd06392; PBP1_iGluR_delta_1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF229; GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|RuleBase:RU367118};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT CHAIN 21..1061
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT /id="PRO_5027134296"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 640..661
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 834..858
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 439..810
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 449..511
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 883..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 118291 MW; 4A4659C6F1A0C764 CRC64;
MELLLIYVSL WILQCISTRA DSIIHIGAIF EENAVRDEEI FQLAISDLSL NDDILQSEKI
THSVKLIEPN NPFQAVQEAC ELMNQGILAL VTSTGCAAAS ALQSLTDAMH IPHLFIQRNA
EGSPRTACQL NPSPDGESYT LAARPPVRIN DVLLTLVSEL HWRKFIIFYE SDYDIRGLQT
FMDQASRLGL DVSLQRVDRN VSRVFTDLFS TMQTEELHRY RDTLRRAVLL MSPRGAQVFI
HQAVETNLAS KDSHWVYANE EVSDPDIMEL VHSSLGRMTI IRQIFPLWRD TNVRCMRNNH
RISSLLCDPQ EGYLQSLEVS NLYLYDSVLM LANAFYRKLE DRKWHSMASL NCMRKSTKPW
NGGWSMLDTI QKGRISGLTG QMDFRAEGSN SHVQFEILGT SYSETFGKDV KRLASWDSTR
GLNGSLKENR IESGMHGVML KIVTVLEEPF VMVAENILGQ PKRYKGFSID VLDALAKLLG
FKYDIYQVGD GKYGTALPNG SWNGMIGEVI GKRADLAVSA ITITPERESV VDFSKRYLDY
SVGILMRKTE DKINIFSLLA PFDLAVWACI AAAIPVVGIM IFLLRRIQTA RCQNSTGGHP
PPSVSTSLQS AIWIVYGAFV QQGSDSVLGT VALRIVMGSW WLFTLIVCSS YTANLAAYLT
VSRMDNAVRS FQDLSKQVDL VYGTVRDSAV YEYFKAKGTN PLEQDNTFAE LWKTINKNNG
FENSVTSPTE GIRKVKQGSY AFLWDMAVVE YAALTDDDCT LTVAGNSLST RGYGMALQHG
SPYRDLFSQK ILELQEKGDL DILKQKWWPK KGRCDVQSYT DAQPEGRSLR LQSFAGVFCI
LAAGLLLALL VAALETWWNS NQCRREQPKE QVTQDFGMDS VSGPMTYSDI TSTSPAGRRD
MWTGRERETG KRLRFLTQDK EVNLEQVHQR LNSLLDEDLA HKQLPGQSIE ISALDISSMQ
PSQSLEALSA RDYSCGPRPI SVTTFLQEGH GTGRTLGAAA GRTLPLPLSS ATMPSIRCKH
RAPNGGLFRQ SPVKTPMPMA YQPVPGGPIP EGSEPGHGTS I
//
