ID A0A3P8UUL9_CYNSE Unreviewed; 591 AA.
AC A0A3P8UUL9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Nuclear receptor subfamily 4 group A member 1-like {ECO:0000313|Ensembl:ENSCSEP00000006077.1};
GN Name=NR4A1 {ECO:0000313|Ensembl:ENSCSEP00000006077.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000006077.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000006077.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000006077.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR4
CC subfamily. {ECO:0000256|ARBA:ARBA00006423}.
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DR RefSeq; XP_008318317.1; XM_008320095.2.
DR AlphaFoldDB; A0A3P8UUL9; -.
DR STRING; 244447.ENSCSEP00000006077; -.
DR Ensembl; ENSCSET00000006142.1; ENSCSEP00000006077.1; ENSCSEG00000003919.1.
DR GeneID; 103386020; -.
DR KEGG; csem:103386020; -.
DR GeneTree; ENSGT00950000183038; -.
DR InParanoid; A0A3P8UUL9; -.
DR OMA; CLREHVS; -.
DR OrthoDB; 5395768at2759; -.
DR Proteomes; UP000265120; Chromosome 11.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR CDD; cd06969; NR_DBD_NGFI-B; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR003070; NR4A1-3.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24085; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24085:SF1; NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01284; NUCLEARECPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 251..326
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 351..588
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 591 AA; 65834 MW; 6C21B6FCEDF68984 CRC64;
MPCVQTQFAS LPHDTYFSSE FLNPDLSAKL VMDISGQKDQ LSTSSLPSIN TLVGNGYAGE
FDAYSCKITT SPPAFTASFS SPTVAESSSA QMQNQAFKLD ELQVYGCYPG SFAFSCLDET
LSSCGSDYYG SPVYGASSPV TPGFQTQPAP SWDSPYSPYS AAPPSSVADK AAMAQQLSFF
TFSATQEQHS PVGHLHDAQL GQDDPFFLPH QQHVSTLHCP TIPMEHRPME SPSTVEGNMM
SNKSQNPATS EGRCAVCGDN ASCQHYGVRT CEGCKGFFKR TVQKNAKYVC LANKDCPVDK
RRRNRCQFCR FQKCLAVGMV KEVVRTDNLK GRRGRLPSKP KTLAEPSSTT PNVNIISTLI
QAHLDSNPSF GKLDYSQYQQ TVENHQEKED ASDIQQFYDL LTGAMDVIRG WAKNIPGFPD
FCSEDQDLLL ESAFVELFIL RLAYRSDPEK DKLIFCNGVV LHRLQCVRSF GDWIDSIMEF
SHSLHRMNLD VSLFSCLAAL VIITDRHGLR EPKRVEDFQN HLITCLREHL NSGASEQTRT
QPNYLSRLLG KLPELRTLCT QGLQRIFYLK LEDLVPPPPI VEKIFMDTLP F
//
