ID A0A3P8UVH6_CYNSE Unreviewed; 1052 AA.
AC A0A3P8UVH6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Toll-like receptor 9 {ECO:0000313|Ensembl:ENSCSEP00000004260.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000004260.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000004260.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000004260.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; A0A3P8UVH6; -.
DR STRING; 244447.ENSCSEP00000004260; -.
DR Ensembl; ENSCSET00000004315.1; ENSCSEP00000004260.1; ENSCSEG00000002760.1.
DR GeneTree; ENSGT00940000163875; -.
DR InParanoid; A0A3P8UVH6; -.
DR Proteomes; UP000265120; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF4; TOLL-LIKE RECEPTOR 9; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1052
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018117910"
FT TRANSMEM 837..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 891..1035
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1052 AA; 121118 MW; 1DBC3512290B7A4E CRC64;
DPSTMEWIFI ISLILPGLWS INLRFFPCDS EMNDTTADCN KRLISKVPFK STELKILKLS
QTKMLQVKAD SFKYVSNLRT LEMMDNCLPA RMRSPDKFCT MEIHYNAFKT LPKLQNLYLS
GNSLTSIPWL PESLLVLDLQ NNHISHISIS LGTPNLRQLL LSKNCFYANP CNRSFHITEK
VFGDLPKLEN LTLGYNNLTE VPKGLPPTLV SLDLKENTIT QVLDGTFSNL TNLTHLVLEW
NCQRCDHAAR PCFPCPNNLP LNLSSNSLYA EKSSIIYLSL RGNSLKTFPE GLFRPLTSLQ
RLDLSDNRLA FEIQNGKFFT ELKNLTWISL IYNYEPLVTF SQLKLSKHIS EMSRLQYLLL
SGIFFHRLSN QSFNVLSSLK HLIKIELRMN FINDSNITAL RKLPSLVNIV LSQNMLAFLP
CIPGTTLNTT LAQNSNQYAY EVQEQPIILR KRETESGNEF PQSGPFNVFD RFEDCSPHFP
SPWEFRNHLC YNNLSVDFSQ NEIASLNRHV FEGMEDVVCL DLSFNYMSER LQTGEFSSMK
NLAFLNLSYN RLDLYHDNVF SELNRTLKVL DVSNNDFHFK MRGMGHRFVF LKNLMNLEVL
SLANNGIGMR IDQALVSSSV KYFYFYGNDL NIMWASDNTK YTHFFQNMTN LMYLDISDNN
LVSISPEVLV NFPRSLKALR VSDNKLKYFP WWNISALFNL CYLDLSGNHL SHLPHEVIPF
GANFTLLDLS SNYISVIPED FLQNSKSLEY LRLDHNQIMA LDRQLLPAPF KNGSALKELS
LHGNPFKCDC DTSWLADFLG TTDIKVAYLT TEVYCKYPES QQGQSVLSMD QRSCQDIYGS
LAFLVCSFLV VLSTVLPLLK HLYGWDMWYC LQVIWAGHKG YSQLAGTNLK DHYDAFVVFD
TGNQAVRDWV YNELTVTLEN RGQRTFSLCL EERDWVPGLS CIDNLHNSVN KSKKTVFVLS
STETINGVIR QAFFMVQQRL LDEKVDTAVL VLLDEKFPKL KYLQLRKKLC RKSVLTWPRN
PRAQPLFWNK MRTVLSSDNL TLYDNNMSES FI
//
