ID A0A3P8UWX6_CYNSE Unreviewed; 896 AA.
AC A0A3P8UWX6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Alpha-actinin-2 {ECO:0000313|Ensembl:ENSCSEP00000007698.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000007698.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000007698.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000007698.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
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DR RefSeq; XP_008320018.1; XM_008321796.2.
DR AlphaFoldDB; A0A3P8UWX6; -.
DR STRING; 244447.ENSCSEP00000007698; -.
DR Ensembl; ENSCSET00000007775.1; ENSCSEP00000007698.1; ENSCSEG00000004955.1.
DR GeneID; 103387249; -.
DR KEGG; csem:103387249; -.
DR CTD; 641575; -.
DR GeneTree; ENSGT00940000153968; -.
DR InParanoid; A0A3P8UWX6; -.
DR OMA; VRYDNGY; -.
DR OrthoDB; 2872403at2759; -.
DR Proteomes; UP000265120; Chromosome 12.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd21214; CH_ACTN_rpt1; 1.
DR CDD; cd21216; CH_ACTN_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF429; ALPHA-ACTININ-2; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 40..144
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 153..259
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 755..790
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 791..826
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 274..301
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 439..473
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 896 AA; 103748 MW; E0A9A070EE63C7E0 CRC64;
MMTMTQVETT IHYDNGYEDE YMLQEDEWDR DMLLDPAWEQ QQRKTFTAWC NSHLRKAGTQ
IENIEEDFRN GLKLMLLLEV ISGERLAKPD RGKMRFHKIA NVNKALDFIT SKGVKLVSIG
AEEIVDGNVK MTLGMIWTII LRFAIQDISV EETSAKEGLL LWCQRKTAPY RNVNVQNFHV
SWKDGLAFCA LIHRHRPDLL DYSKLNKDDP MGNLNLAFDI AEKHLDIPKM LDAEDIINTP
KPDERAIMTY VSCFYHAFAG AEQAETAANR ICKVLGVNQE NEKLMEEYER LASELLEWIR
RTTPWLENRT PEKTMAEMQQ KLEDFRDYRR QHKPPKVQEK CQLEINFNTL QTKLRISNRP
AFMPSEGKMV SDIATAWQGL EQAEKGYEEW LLTEIRRLER LDHLAEKFRQ KATNHENWAD
GKEQILSQKD YETTTLTEIR ALLRKHEAFE SDLAAHQDRV EQIAAIAQEL NELDYHDVAA
VNQRCQSICD LWDKLGTLTQ KRREALERTE KLLETIDQLF LEFSKRSAPF NNWMEGAMED
LQDMFIVHTI EETQSLIAAH EQFKATLPEA DAERQAILGI HNEVLKISQS YGIKANITNP
YSTITTEELL NKWEKVKKLV PQRDGALQEE MARQHAHERL RRQFAAQANL IGPWIQARME
EIGRCSLEIR GALEDQMTQL KQCEHVIVAY KPNIDKLEGD HQLIQESLVF DNKHTNYTME
HIRVGWELLL TTIARTINEI ETQILTRDAK GISQQQMNEF RSSFSHFDRK KNGAMETDDF
RACLISMGYD LGEVEFARIM ILVDPNGTGI VSFQSFIDFM TRETADTDTA EQVVASFRIL
AADKPYILVE ELRRELPPEQ AEYCIMRMPP YKVHGAPPGA LDYTAFSTAL YGESDL
//