ID A0A3P8UY11_CYNSE Unreviewed; 464 AA.
AC A0A3P8UY11;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Clusterin {ECO:0000256|ARBA:ARBA00020334, ECO:0000256|RuleBase:RU000629};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000005661.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000005661.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000005661.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, secretory
CC vesicle, chromaffin granule {ECO:0000256|ARBA:ARBA00004248}.
CC Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004346}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004346}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004346}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the clusterin family.
CC {ECO:0000256|ARBA:ARBA00010069, ECO:0000256|RuleBase:RU000629}.
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DR RefSeq; XP_008311637.1; XM_008313415.2.
DR AlphaFoldDB; A0A3P8UY11; -.
DR STRING; 244447.ENSCSEP00000005661; -.
DR Ensembl; ENSCSET00000005721.1; ENSCSEP00000005661.1; ENSCSEG00000003653.1.
DR GeneID; 103381179; -.
DR KEGG; csem:103381179; -.
DR CTD; 1191; -.
DR GeneTree; ENSGT00530000063668; -.
DR InParanoid; A0A3P8UY11; -.
DR OMA; QGSKYIN; -.
DR OrthoDB; 4321242at2759; -.
DR Proteomes; UP000265120; Chromosome 7.
DR GO; GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR000753; Clusterin-like.
DR InterPro; IPR016015; Clusterin_C.
DR InterPro; IPR033986; Clusterin_CS.
DR InterPro; IPR016014; Clusterin_N.
DR PANTHER; PTHR10970; CLUSTERIN; 1.
DR PANTHER; PTHR10970:SF1; CLUSTERIN; 1.
DR Pfam; PF01093; Clusterin; 1.
DR SMART; SM00035; CLa; 1.
DR SMART; SM00030; CLb; 1.
DR PROSITE; PS00492; CLUSTERIN_1; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..464
FT /note="Clusterin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018165661"
FT DOMAIN 35..230
FT /note="Clusterin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00030"
FT DOMAIN 231..457
FT /note="Clusterin C-terminal"
FT /evidence="ECO:0000259|SMART:SM00035"
FT COILED 68..116
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 464 AA; 53126 MW; C1DCE73CD731F445 CRC64;
MLMMMMMMKK KKNGLKSLAV VALFLATANC IVPPSKDDLN EISRQGEKYL DKQIETAING
VQEMKNVMQK STEEHQKYLD ALEKTKQLKE DALRKAQEME AKLEEEEEVC NETMKTLWEE
CKPCLKNTCV KYYSRTCSTG SGLVGRQLED ILNRTSPISI WINGEKIDVL EQEDRRQKNQ
LKNLEDKYTV MADGVDSIFT DSMKVADHVH YNPPSFFLPT FFGPYSRHRR GIRSIFQNPF
HGFHNMFSPM MGMGRNLFGS MDSMMDVDIT SDEDTNMNED VVITKPFGNG RMTCREIRRN
SAGCIKFRDE CQKCKDIQHI DCSGKKPLEG PLKEELENAL ALAERFTQRY NSLLRRFEEQ
MFNTSSVLDL FNRQFGWVSS LANSTDSSDG LFHVLTVTCN DNEKTSDEEK QESPAETDVS
VKLFDSPTLN ISVPGDIPWT DPKFSEVVAQ EALDRYKENA VIVK
//
