ID A0A3P8UY83_CYNSE Unreviewed; 175 AA.
AC A0A3P8UY83;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Insulin like growth factor 1 {ECO:0000313|Ensembl:ENSCSEP00000007312.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000007312.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000007312.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000007312.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR AlphaFoldDB; A0A3P8UY83; -.
DR Ensembl; ENSCSET00000007389.1; ENSCSEP00000007312.1; ENSCSEG00000004697.1.
DR GeneTree; ENSGT00940000159081; -.
DR OMA; NECCFQS; -.
DR Proteomes; UP000265120; Chromosome 8.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022341; IGF-I.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46845:SF3; INSULIN-LIKE GROWTH FACTOR 1; 1.
DR PANTHER; PTHR46845; INSULIN-LIKE GROWTH FACTOR I; 1.
DR Pfam; PF00049; Insulin; 2.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02005; INSLNLIKEGF1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..41
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 42..175
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018081614"
FT DOMAIN 48..104
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 114..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 51..91
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 63..104
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 90..95
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ SEQUENCE 175 AA; 19358 MW; 237436230139E094 CRC64;
MSISAPSFQW HFWDVLKSAM CCISCSHTLS LLLCVLTLTQ AAAGAGPETL CGAELVDTLQ
FVCGERGFYF SKPTGYGPNS RRSRGIVDEC CFQSCELRRL EMYCAPAKTG KAARSVRAQR
HTDLPRAPKV STPGHKADKG QERRTAQQPE KTKNKKEVHQ KNSSRGNSGG RNYRM
//
