ID A0A3P8UYA7_CYNSE Unreviewed; 1957 AA.
AC A0A3P8UYA7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Myosin-9 {ECO:0000256|ARBA:ARBA00039816};
DE AltName: Full=Myosin heavy chain 9 {ECO:0000256|ARBA:ARBA00041440};
DE AltName: Full=Myosin heavy chain, non-muscle IIa {ECO:0000256|ARBA:ARBA00042289};
DE AltName: Full=Non-muscle myosin heavy chain IIa {ECO:0000256|ARBA:ARBA00043098};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000005215.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000005215.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000005215.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, Cortical
CC granule {ECO:0000256|ARBA:ARBA00037865}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 244447.ENSCSEP00000005215; -.
DR Ensembl; ENSCSET00000005272.1; ENSCSEP00000005215.1; ENSCSEG00000003348.1.
DR GeneTree; ENSGT00940000155632; -.
DR InParanoid; A0A3P8UYA7; -.
DR OMA; DLCLEDY; -.
DR Proteomes; UP000265120; Chromosome 9.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF16; MYOSIN-9; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 25..75
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 79..776
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 654..676
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1258..1279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1328..1352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1695..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1864..1919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1933..1957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1336..1352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1864..1908
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 175..182
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1957 AA; 227022 MW; 5D8456FC9510F9B5 CRC64;
MTDADKFLYG DRSGVNNPLV QADWSSKKLV WVPSEKMGFE AGSLKEEHGE ECVVELTDSG
KKVKVNKDDI QKMNPPKFNK VEDMAELTCL NEASVLHNLK DRYYSGLIYT YSGLFCVVVN
PYKYLPIYTE DIVNMYKGKK RHEMPPHIYA ITDTAYRSMM QVDMTELFHF LLYSGESGAG
KTENTKKVIQ YLAHIASSSK SKKDQGELEK QLLQANPILE AFGNAKTVKN DNSSRFGKFI
RINFDVNGYI VGANIETYLL EKSRAIRQAK EERSFHVFYY LLTGAGDKMR SQLCLEDYSK
YRFLSNGNVT IPGQQDKDMF AETMEAFNIM SIPEEEVTGL LKVVSAVLQL GNMSFKKERN
SDQASMPDDT AAQKVCHLLG INVTDFSRAI LSPRIKVGRD YVQKAQTQEQ AEFAVEALAK
ASYERMFRWL VMRINKALDK TKRQGASFIG ILDIAGFEIF ELNSFEQLCI NYTNEKLQQL
FNHTMFILEQ EEYQREGIEW SFIDFGLDLQ PCIDLIEKHA GPPGILALLD EECWFPKATD
KSFVEKVVQE QGTHPKFQKP KKLKDDVDFC VMHYAGKVDY KADEWLMKNM DPLNESVATL
LNQSTDKITC DLWRDVDRIV GLDKVAGMSD SMHGAFKTRK GMFRTVGQLY KEQLGNLMAT
LRNTNPNFVR CIIPNHEKKA GKLEPHLVLD QLRCNGVLEG IRICRQGFPN RIVFQEFRQR
YEILTPNAIP KGFMDGKQAC VLMIKALELD PNLYRIGQSK VFFRAGVLAH LEEERDMKIT
DVIISFQAWC RGHLARKAFA KRQQQLTAMR VIQRNCAAYL KLRNWQWWRL FTKVKPLLQV
TRQEEEMVAK EEELVKVKER QVQAEEQLRE FESKQQQLNA EKQALQEQLQ AETELCAEAE
EMRARLAIRK QELEEILHDL ESRLEEEEER VTHMQTERKK MQQNITDLEQ QLDEEEAARQ
KLQIEKVTTD AKLKKMEEDI MVLDDQNIKL NKEKKQMEER ISEFTTNLTE EEEKSKSLQK
LKNKHEAMIT DLEDRLRKEE KVRQELEKNR RKLEGDSTEL HDQIADLQAQ IDELRAQLAK
KEEELHAALA RIEEESAAKN MAQKKIRELE AQISELQEDL ELERQARSKA EKHRRDLGEE
LEALKTELED TLDSTAAQQE LRSKRETEVA HLKKTLEEEA KVHEQQMADM RQKHNQTFEE
LNEQLEQAKR NKASVEKTKQ ALESELNELQ IELQSLTQGK GDSEHRRKKA EAQVQELQVK
FGESEKQRQE QSSKITKMQS ELDNVNSLLS EADGKNIKSS KDISSLESQL QDAQELLQEE
TRQKLAISSQ LRQMESDHTS LRDMLEEEEE AKRNADKQIS ALQAQLGELK KKLEVEALSL
EGAEEGRKRV QREVDSVMQQ LEEKTAAYDK LDKTKTRLQQ ELDDLLVDQD NLRQIVSNLE
RKQKKFDQML AEEKTISTQY AEERDRAEAE AREKETRALT LGRELETMTD MKAELDRVNK
QLKAEMEDLV SSKDDVGKSV HELERSKRAM EQQLEEMRVQ LEELEDELQT TEDAKLRLEV
NMQAMKAQFD RDLQARDEQG EEKRKLLVKQ VREMELELED ERRQKTQAVS AKKKLDLDLA
DLQVQIDDAN KGRDEALKQL KKLQVQMKDL MRELDELRMS RDDAVNSAKE TEKKLKTMET
DALHLQEDLA TAERLRRQAQ TERDELQEVV NSSNSKNSQL ADEKRRLEAR ITQLEEDLEE
EQLNSEMVND RMKRATLQSE QLTTELAGER SNSQKVEGAR AQLDRQNKEL KLKLQELEGT
IKSKYKSSIT TLEAKIAMLE EQLDTESKER QQASRLVRRT EKKLKEALLQ VDDERRNMDQ
YKDQVEKTNS RMRQLKRQLE ETEEELTRSN ANRRKLQRDL EDASESADAM NREVSSLKSK
LRRGDIPFNM QRIRIRPGVD SDDDADVPAE VPESTAE
//
