ID A0A3P8UYF8_CYNSE Unreviewed; 1018 AA.
AC A0A3P8UYF8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Myosin IC {ECO:0000313|Ensembl:ENSCSEP00000008208.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000008208.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000008208.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000008208.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium membrane
CC {ECO:0000256|ARBA:ARBA00004289}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; A0A3P8UYF8; -.
DR STRING; 244447.ENSCSEP00000008208; -.
DR Ensembl; ENSCSET00000008294.1; ENSCSEP00000008208.1; ENSCSEG00000005253.1.
DR GeneTree; ENSGT00940000157915; -.
DR InParanoid; A0A3P8UYF8; -.
DR OMA; FICRGNC; -.
DR Proteomes; UP000265120; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0060171; C:stereocilium membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF255; UNCONVENTIONAL MYOSIN-IC; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 12..692
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 840..1014
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 569..591
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 105..112
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1018 AA; 116822 MW; FE6A1A78E9927909 CRC64;
MESALTARDR VGVQDFVLLE NYTSEAAFIE NLRKRFKENL IYTYIGSVLV SVNPYKDLEI
YTKNHMERYR GVNFYEVSPH IYAVADNSYR SMRTERKDQC ILISGESGAG KTEASKKILQ
YYAVTCPASD QVQTVKDRLL QSNPVLEAFG NAKTLRNDNS SRFGKYMDIQ FDFKGAPVGG
HIINYLLEKS RVVHQNHGER NFHIFYQLIE GGEEDLLRRL GLERNPQQYQ YLVKGNCPKV
SSINDRSDWK VVKKALSVIG FNEDDVEELL NIIASVLHLG NVQYGDEEGN ACITSDTQIK
YLARLLGVNG TVLTEALTHK KIIAKGEELM SPLNLEQASY ARDALSKAVY GRTFTWLVNK
INASLSYKDD SSKTYSVIGL LDIYGFEVFQ NNSFEQFCIN YCNEKLQQLF IELTLKSEQE
EYESTSITWE PVQYFNNKII CDLVEEKFKG IISILDEECL RPGDASDITF LEKLEDIVGG
HAHFVTHKLA DGKTRKVMGR DEFRLQHYAG EVNYNVNGFL DKNNDLLFRN LKEVMCMSEN
NILNQCFNKE ELSDKKRPDT AATQFKASLA KLMEILMSKE PSYVRCIKPN DSKQAGRFDE
VLIRHQVKYL GLMENLRVRR AGFAYRRRYE VFLQRYKSLC PDTWPNWQGK LADGVATLVK
HLGYKPEEYK LGRSKIFIRF PKTLFSTEDA LETRKHSLAV MDVVYLSAIA VQAWWRGILA
RRRAKQRRQA VDTIRRKKKK KQHLFVKGFI YRHKERCPEN EYFLDYVRYS FLMKLHRNLP
KNVLDKSWPT PPAALTEASE HLRKLCMQNM VWSYCKKISP EWKHQMEQKA IASELFKDKK
DNYPQSVPKL FLSTRLNGED INPKALQTLG SEKMKYGVPV TKYDRKGYKA RPRQLLLTGN
SAIIIEEAKV KQRIDYAALK GISVSSLSDG LFVLHVPSED NKQKGDVVLQ SDYVIETLTK
IAICADKINS ININQGSIKF TGTQGKEGII DFTPGSELLV AKAKNGHLSV TAPRLNSR
//
