ID A0A3P8UZB0_CYNSE Unreviewed; 1076 AA.
AC A0A3P8UZB0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Integrin alpha-6-like {ECO:0000313|Ensembl:ENSCSEP00000008488.1};
GN Name=ITGA6 {ECO:0000313|Ensembl:ENSCSEP00000008488.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000008488.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000008488.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000008488.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3P8UZB0; -.
DR Ensembl; ENSCSET00000008577.1; ENSCSEP00000008488.1; ENSCSEG00000005423.1.
DR GeneTree; ENSGT00940000155353; -.
DR OMA; CERVDFD; -.
DR Proteomes; UP000265120; Chromosome 16.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF9; INTEGRIN ALPHA-6; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 37..1076
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5017851008"
FT TRANSMEM 1018..1040
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 41..105
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 256..313
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 315..376
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 377..434
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 437..497
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 482..642
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 644..797
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 801..1006
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1076 AA; 118422 MW; AE5437607C7924C5 CRC64;
MMLLPSLPGG HFSVHAHVCA ALLLLSCLLQ PSAVLAFNLD TGHVLKKSGE PGSLFGFSLA
LHRQLHPDHR MLLIGAPRAR ALGQQTANIT GGLYKCDITS SNECERINFD VEEDVRYENK
EDQWMGVTVQ SQGPGGKIVT CAHRYQRRLF VNTPQESRDI TGRCYVLSQD LTIDLSSDED
GGNWNFCEGR ARGHEMFGSC QQGLAATFTK DYHYVVFGAP GAYNWKGVVR VEQKNNTLLD
LGVYDDGPYE VGDENLLNPE LVPVPANSYL GFSLDSGHSI TRARGLTVVA GAPRANHSGA
VVLLRKESEA STRLSVEHTL QGQGLGSSFG YDVAVVDLNA DGWQDVVVGA PQFYMKDSDV
GGAVYVYINQ AGRWEDVTPV RLDGARDSMF GLAVENIGDV NQDAYKDIAV GAPYEDGGAG
KVYIYHGSAQ GIKTTPAQIL SGQDHKLQLF GYSLAGNMDL DLNSYPDLAV GSLSDTALIY
RARPVISIRR DVKISPQEID LTIKNCGNSI CVTVDACFDY TANTKSYSSR LTISYSIEAD
GDRRKQGLPP RVMFMNKSTS DTDYLFTGTM ELRGQKQETC IKIEAKLKEN IKDKMHSIPV
EVSAHIVSTK RQKTKNGLPQ LTPILDSSQP DKDVVEVNFV KEGCGSDHIC RSNLKMQYKL
HYKQNTRHSP LPIKNNLPVF HLNYERKDLA LRVTVSNANG DDAYEAKLLA TFPDTVSYSG
VRSHQTVPII CVANQNGSQA DCELGNPFKR DSESTFYIIL STVAMSLDTT ELEFDLQLQT
TSVQTIDQVR VKARVTIELP LTLSGEASPN LVSFGGVVKG ESAMTTEEEI GGLINYAFRV
NNLWKTLKPS IKPSLHIHWP KFNRDGKWLL YLVKVTAAGE ENVRCSPQSE ISSLKHIKES
TVPRTKREIE RKGKKVVGKL SSPSDKDRIL SCENGMKCVV LKCPLKGLDG TTVELRSRLW
NSTFIEDYTS VPTLHIVVKA TLVLHGQAEN MILTTPDTKV TVAVSPESTV AHYGGVPWWI
ILVAVLAGIL ILALLVFLLW KCGFFKRAIK DQYDAAFHKA KISVQLSDKD KLSAEA
//
