ID A0A3P8UZM3_CYNSE Unreviewed; 423 AA.
AC A0A3P8UZM3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Bone morphogenetic protein 7-like {ECO:0000313|Ensembl:ENSCSEP00000007299.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000007299.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000007299.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000007299.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_008318427.1; XM_008320205.2.
DR AlphaFoldDB; A0A3P8UZM3; -.
DR STRING; 244447.ENSCSEP00000007299; -.
DR Ensembl; ENSCSET00000007378.1; ENSCSEP00000007299.1; ENSCSEG00000004712.1.
DR GeneID; 103386095; -.
DR KEGG; csem:103386095; -.
DR GeneTree; ENSGT00940000156490; -.
DR InParanoid; A0A3P8UZM3; -.
DR OMA; HKGRQSN; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000265120; Chromosome 11.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0048264; P:determination of ventral identity; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0021703; P:locus ceruleus development; IEA:Ensembl.
DR GO; GO:0042664; P:negative regulation of endodermal cell fate specification; IEA:Ensembl.
DR GO; GO:0036342; P:post-anal tail morphogenesis; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR CDD; cd19397; TGF_beta_BMP7; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF135; BONE MORPHOGENETIC PROTEIN 7; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 294..423
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 423 AA; 48686 MW; BB485A404E0D67F2 CRC64;
MLTRAYATVA TLVSLSYCVM ATQVFFSNFS ADNEVRSSFI QRRLRSQERR EMQREILSIL
GLPHRPRPLV HTKHDAAPMF MLDLYNTIST DTQPQSYSYK SVFQHQAPMV TPQDNRFLSD
ADMVMSFVNL VDQDPEFLYQ NHRREFRFDL SRIPEGEAVT AAEFRIYKDF IQERSENETF
KVSLYQVLQT HSNSEVELLL LDQRHIWASE DGWLVFDLTH TSKFWLVKPE KNLGLHLVVE
DGHGQRRNPH LAGLVTGSRP QNKQPFMVVF FKASEVRFRS IRSAQGQKGR QSNRSKPQRT
VQDALKAVEA ATDNLGFSKE GCKKHELFVS FRDLGWQDWI IAPDGYAAYY CEGECAFPLN
SYMNATNHAI VQTLVHFINP ESVPKPCCAP TQLHGISVLY FDDSSNVILK KYRNMVVRAC
GCH
//
