ID A0A3P8UZN2_CYNSE Unreviewed; 590 AA.
AC A0A3P8UZN2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Phosphoglucomutase 2 {ECO:0000313|Ensembl:ENSCSEP00000007797.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000007797.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000007797.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000007797.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the phosphohexose mutase family.
CC {ECO:0000256|ARBA:ARBA00010231, ECO:0000256|RuleBase:RU004326}.
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DR AlphaFoldDB; A0A3P8UZN2; -.
DR STRING; 244447.ENSCSEP00000007797; -.
DR Ensembl; ENSCSET00000007879.1; ENSCSEP00000007797.1; ENSCSEG00000005011.1.
DR GeneTree; ENSGT00940000156247; -.
DR InParanoid; A0A3P8UZN2; -.
DR OMA; HVTKASY; -.
DR Proteomes; UP000265120; Chromosome 9.
DR GO; GO:0016868; F:intramolecular phosphotransferase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd05799; PGM2; 1.
DR Gene3D; 3.40.120.10; Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3; 4.
DR InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
DR InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
DR InterPro; IPR005845; A-D-PHexomutase_a/b/a-II.
DR InterPro; IPR005846; A-D-PHexomutase_a/b/a-III.
DR InterPro; IPR036900; A-D-PHexomutase_C_sf.
DR InterPro; IPR016066; A-D-PHexomutase_CS.
DR InterPro; IPR005841; Alpha-D-phosphohexomutase_SF.
DR PANTHER; PTHR45745; PHOSPHOMANNOMUTASE 45A; 1.
DR PANTHER; PTHR45745:SF3; PHOSPHOPENTOMUTASE; 1.
DR Pfam; PF02878; PGM_PMM_I; 2.
DR Pfam; PF02879; PGM_PMM_II; 1.
DR Pfam; PF02880; PGM_PMM_III; 1.
DR PRINTS; PR00509; PGMPMM.
DR SUPFAM; SSF55957; Phosphoglucomutase, C-terminal domain; 1.
DR SUPFAM; SSF53738; Phosphoglucomutase, first 3 domains; 3.
DR PROSITE; PS00710; PGM_PMM; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|RuleBase:RU004326};
KW Metal-binding {ECO:0000256|RuleBase:RU004326};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 54..109
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02878"
FT DOMAIN 125..174
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02878"
FT DOMAIN 205..310
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02879"
FT DOMAIN 321..449
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02880"
SQ SEQUENCE 590 AA; 65113 MW; 59E56388EFAF6F6E CRC64;
RKCNMGDGTG DIELDQAVSQ WLQYDQNPKT ASLVQDMMKE GAVDALKKCF SSRMEFGTAG
LRAAMGPGVS CMNDLTIIQT TQGFCHYLEE SFENLKERGV VIGYDARAHP PSGGSSKPLA
VSLQPFTVSH LGLCAGIMVT ASHNPKQDNG YKVYWENGAQ IVSPHDKGIS KAIEINLEPW
PESWNAEEAL KSPLLKDPYQ DIHTQYFKAI QKHCHHRGVN KSSEVKIVHT SVHGVGHAFV
QAAFKAFDLP APFAVEEQKD PDPEFPTVKY PNPEEGEGVL TLSFALAGRE GATVVLANDP
DADRLAVAEK QESGQWQVFS GNELGALLGW WMFRCWKQQN PEADAVKNLY MLSSTVSSKI
LRAIAVKEGF HFEETLTGFK WMGNRAKELL DQGKSVLFAF EEAIGYMCSP FVLDKDGVSA
AAIAGEMISF LATKNISLSQ QLTTIFTEYG YHISKNSYFI CHDQTVIRTL FDRLRNYGGQ
KDSYPSDCGG FSISSVRDLT TGYDSNQPDK KAVLPTSSSS QMITFSFSNG GVATMRTSGT
EPKIKYYTEL CAAPGNSDVK HLKKELDDLV KAIVENFFEP QKNKLQPKPE
//
