ID A0A3P8UZU3_CYNSE Unreviewed; 1684 AA.
AC A0A3P8UZU3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000007862.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000007862.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000007862.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR Ensembl; ENSCSET00000007947.1; ENSCSEP00000007862.1; ENSCSEG00000005020.1.
DR GeneTree; ENSGT00940000163423; -.
DR Proteomes; UP000265120; Chromosome 14.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF278; SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 170..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 201..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 346..365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 385..412
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 596..614
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 626..649
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 706..734
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 799..819
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 895..913
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 934..953
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 959..981
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1026..1046
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1093..1114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1134..1157
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1215..1233
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1245..1263
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1275..1295
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1332..1360
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1434..1459
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 110..418
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 595..819
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 823..888
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 893..1166
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1214..1469
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 31..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1642..1684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 409..443
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 31..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1662..1684
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1684 AA; 192361 MW; 7AB4DABAA5A2A300 CRC64;
MAQLLVPPGP DSFHPFVPES LAAIERRIAE EAAKRPKADR RSDSDDENGP KPNSDLEAGK
SLPFIYGDIP PKLVSTPLED MDTYYSNQKT FIVLNRGKVI FRFNATPAFV LIMFTILTNC
AFMTLSNPPD WAKNVEYTFT GIYTFESLIK ILARGFCVGK FTFLRDPWNW LDFSVILMAY
VTEFVDLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI LTVFCLSVFA
LIGLQLFMGN LRQKCVRMPV AGNASNSSSN EMDDSMFIIN ATVDFNTVFG MNVSESPFNW
TEYMRDEDNY YYLPGHKDAL LCGNGSGAGL CPEGFSCIKA GRNPDYGYTS FDTFSWAFLS
LFRLMTQDYW ENLYQQTLRA AGKPYMIFFV LVIFLGSFYL VNLILAVVAM AYEEQNQATI
EEAQQKEEEF QAMLEQLKRQ QEEAQLPGIL HCSIHPRAFE TSMGYHNNNC ACALIGWQVA
AAAATATESG EYSGRGGPTS ESSSGTSKLS SKSAKERRNR RKKRKQREEE EEREGRKFHK
SESEDSIKRS SFQLEESRQK CPPCWYRFAN TCLIWDCCPA WLRIKEIVNM VVMDPFVDLA
ITICIVLNTL FMAMEHYPMT EEFDTVLTVG NLVFTGIFTA EMCFKIIALD PYYYFQEGWN
IFDGIIVSLS LMELGLSNVE GLSVLRSFRL LRVFKLAKSW PTLNMLIKII GNSVGALGNL
TLVLAIIVFI FAVVGMQLFG KSYKECVCKI SSDCELPRWH MHDFLPHRWH MNDFFHSFLI
VFRILCGEWI ETMWDCMEVA GQTMCLIVFM MVMVIGNLVP RPLSSSEGST VDIRPPGDGV
DSVELEPEES LDPEPCFTEG CVRRFQCCQV NEDGSNYKNW WTLRKTCFII VEHNWFESFI
IFMILLSSGA LAFEDVYIEQ RRTIKTMLEY ADKVFTYVFI LEMLLKWVAY GFVKYFTNAW
CWLDFLIVDV SLVSLVANAL GYSELSAIKS LRTLRALRPL RALSRFEGMR VVVNALLGAI
PSIMNVLLVC LIFWLIFSIM GVNLFAGKYY YCVNTTTDEP FPITQVNNKT DCLNLANDSA
RWKNVKINFD NVGAGYLALL QVATFKGWTF IMYAAVDSRD VEDQPDYEVN LYMYLYFVIF
IIFGSFFTLN LFIGVIIDNF NQQKKKMSQD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPT
NTFQGCVFDC ITKQAFDIVI MILICLNMVT MMVETDDQTP EMALNLYWIN MVFIVLFTGE
CVLKMISLRH YYFTIGWNIF DFVVVILSIV GMFLSEVIEK YFVSPTLFRV IRLARIGRIL
RLIKGAKGIR TLLFALMMSL PALFNIGLLL FLVMFIYAIF GMSNFAYVVR EAGIDDMFNF
ETFGNSMICL FQITTSAGWD GLLAPILNKR EPDCDSQVEH PGNPYRGNCG NPSVAIFFFV
SYIIICFLIV VNMYIAVILE NFSVATEESA EPLSEDDFEM FYEVWERFDP DATQFMEYSK
LSDFADALDP PLRIPKPNMI QLISMDLPMV SGERIHCLDI LFAFTKRVLG EGGEMDMLRG
QMEERFMASN PSKVSYEPIT TTLRRKQEEM SATIIQRAFR NYMIRLAMKK ASCLYKEQLK
EGVRDPDKDV MVICKFTENS TSDKTDMTAS TASPPSYNSV TKSDKDKYEK ENREKENKGR
EGKK
//
