ID   A0A3P8V096_CYNSE        Unreviewed;       567 AA.
AC   A0A3P8V096;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Keratin, type II cytoskeletal 8-like {ECO:0000313|Ensembl:ENSCSEP00000007509.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000007509.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000007509.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000007509.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   RefSeq; XP_008318459.1; XM_008320237.2.
DR   AlphaFoldDB; A0A3P8V096; -.
DR   STRING; 244447.ENSCSEP00000007509; -.
DR   Ensembl; ENSCSET00000007588.1; ENSCSEP00000007509.1; ENSCSEG00000004850.1.
DR   GeneID; 103386113; -.
DR   KEGG; csem:103386113; -.
DR   GeneTree; ENSGT00940000161090; -.
DR   InParanoid; A0A3P8V096; -.
DR   OMA; HSNVDAM; -.
DR   OrthoDB; 4640531at2759; -.
DR   Proteomes; UP000265120; Chromosome 11.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF61; KERATIN, TYPE II CYTOSKELETAL 8; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT   DOMAIN          129..440
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          514..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          133..265
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          338..418
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   567 AA;  63104 MW;  F8E3F8D1694EBAC7 CRC64;
     MSVRAVKTTT YSTKSSSRGP TQGFSSRSFS GYGGGRQNYA VRSSYGGVGS SGAAMGVGGY
     KVGGGFVAGG AVQRGGGVEF GYVGFGGGMG GCMVNETVAP ITAVTVNKSL LAPLNLEIDP
     TIQSIRTEEK EQIKTLNNRF ASFIDKVRFL EQQNKMLETK WKLLQEQTTS RSNVDAMFEA
     YINNLRRQLD NLGHEKVKLE SELLHTTGQV EDFKNRYEEE IHRRNECENN FVLLKKDTDA
     AYLIKVELEA KLDGLSDEID FLRQIFEAEI CELQAQIKDT SVVVEMDNSR NLDMDAIVAE
     VRAQYEDIAN KSRAEAESWY QNKYIEMQQS AGRYGDDLKS TKAEISEMNR MILRLQSEID
     HIKAQRSNLE NQIAEAEERG ELAVKDAKMR VRDLEEALQR AKQDMALQVR QYQELMNVKL
     ALDIEIATYR KLLEGEEDWL ATGIKTNVTK QTSVNYSAFA LESSRTPSYV TGCFGGVKVG
     GGSFAIGDVG VSVEAPSVKS STVTKTETVV IKTEEKKTEE QEEMKEGEVE KEQQAVVEEV
     AVEEKQEKEQ EQEQVKAEAE VEPAAKE
//