ID A0A3P8V0B9_CYNSE Unreviewed; 1211 AA.
AC A0A3P8V0B9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Cullin-associated NEDD8-dissociated protein 1 {ECO:0000256|ARBA:ARBA00040131};
DE AltName: Full=Cullin-associated and neddylation-dissociated protein 1 {ECO:0000256|ARBA:ARBA00042178};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000006481.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000006481.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000006481.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CAND family.
CC {ECO:0000256|ARBA:ARBA00007657}.
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DR AlphaFoldDB; A0A3P8V0B9; -.
DR STRING; 244447.ENSCSEP00000006481; -.
DR Ensembl; ENSCSET00000006553.1; ENSCSEP00000006481.1; ENSCSEG00000004187.1.
DR GeneTree; ENSGT00390000017740; -.
DR InParanoid; A0A3P8V0B9; -.
DR OMA; AYIPHFQ; -.
DR Proteomes; UP000265120; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0010265; P:SCF complex assembly; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039852; CAND1/CAND2.
DR InterPro; IPR013932; TATA-bd_TIP120.
DR PANTHER; PTHR12696:SF1; CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR12696; TIP120; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF08623; TIP120; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1021..1183
FT /note="TATA-binding protein interacting (TIP20)"
FT /evidence="ECO:0000259|Pfam:PF08623"
FT REGION 292..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..319
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 133736 MW; D4E6BC0EE2B08AEA CRC64;
MASASYHISN LLEKMTSSDK DFRFMATNDL MTELQKDSIK LDDDSERKVV RMILKLLEDK
NGEVQNLAVK CLGPLVSKVK EYQVETIVDT LCTNMLSDKE QLRDISSIGL KTVIGELPPA
SSGSALAASV CKKITGRLTS AIAKQEDVSV QLEALDIMAD MLCRQGGLLV NFHPSILSCL
LPQLTSPRLA VRKRTIMALG HLVMSCGNLV FIDLIEHLLT ELGRNDNMST TRTYIQCTAA
ISRQAGHRIG EYLEKIIPLV VKCPKEVYPH VPTVISICLR YLTYDPNYNF DDEDEDDNAM
DAEQNDEDYQ GSDDEYSDDD DMSWKVRRAA AKCLDAVVST RHEMLPEFYR SVSPALVCRF
KEREENVKAD VFHAYLSLLK QTRPAQSWLA DPDAMEQGDT PLTMLQSQIP IIVKALHKQL
KEKSVKTRQC CFNMLTELVN VLPGALTQHI PILIPGIIFS LNDKSSSSNL KIDALACLHV
IMVTHPAHAF HVHVPALVPS VVACVGDPFY KITSEALLVT QQLVKVIRPL DGSSEGPDTF
DPSPYINDLF TCTIKRLKAA DIDQEVKERA ISCMGQIICN LGDRLPAELP GTLLIFLERL
KNEITRLTTV KALTLIAGSP LKIDLRPVLP DAVPILASFL RKNQRALKLC TLAALDILLR
NYSSAVTPVM VDAVLAELPP LISESDMHVS QMALSFLSTL AVTHQSSLGH LSGGNILQQL
IALVRSPLLQ GGALAAMLDF YQALVATETP GLGYMDLLRM LTGPVYSQSA ALPHKQAYCS
IAKCVAALTR ACPTEGPAVV GQFIQDVKNS RSTDSIRLLA LLSLGEVGHH VDLSNQPELK
SVILDAFSSS SEEVKSAASY ALGSIAVGNL PEYLPFVLQE ISSSKRQYLL LHSLKEIISS
ASVSGLKPYV ESIWTLLLKH SECQEEGTRN VVAECLGKLT LIDPETLLPR LKGYLLSGSS
YARSSVVTAV KFTISDQPQP IDPLLKNCIG DFLKTLEDPD LNVRRVALVT FNSAAHNKPS
LIRELLDSVL PQLYNETKVR KELIREVEMG PFKHTVDDGL DLRKAAFECM YTLLDSCLDR
IDIFTFLNHV EDGLKDHYDI KMLTFLMLAR LSSLCPSAVL QRLDRLVEPL RATCTTKVKA
NSVKQEFEKQ DELKRSAMRA VVALLTIPEA EKSPLMSEFQ SQISSNQELA AIFDSIQRDS
TSANMESMDT S
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