ID   A0A3P8V1M9_CYNSE        Unreviewed;       946 AA.
AC   A0A3P8V1M9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=NACHT, LRR and PYD domains-containing protein 12-like {ECO:0000313|Ensembl:ENSCSEP00000008472.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000008472.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000008472.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000008472.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8V1M9; -.
DR   STRING; 244447.ENSCSEP00000008472; -.
DR   Ensembl; ENSCSET00000008561.1; ENSCSEP00000008472.1; ENSCSEG00000005378.1.
DR   GeneTree; ENSGT01100000263513; -.
DR   InParanoid; A0A3P8V1M9; -.
DR   OMA; HYNRETI; -.
DR   Proteomes; UP000265120; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd16040; SPRY_PRY_SNTX; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00368; LRR_RI; 3.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT   DOMAIN          144..278
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   DOMAIN          757..946
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   946 AA;  107077 MW;  039BC1A05ECA77E4 CRC64;
     IQKVLGPDYL KSSESQREDE EVSEGEDEEQ RRSNREAFLK ITENFLRTMK QDKLVDHLGQ
     RQLKSTLKNK FQHLFEGVAQ TGNPTLLNQV FTELHLTEGG AAEVNNEHEV RQIETASLKP
     HRPEEPMRHE DLFKTAPGRP GPVRTVMTRG VAGIGKTVLT QKFTLDWAED RAHQDVHFIF
     PFSFRELNVV KEKKFSLMEL IHHFFTETKD TGICSFDQFK VIFIFDGLDE CRLPLDLHGT
     EVLTDVTEST SVQVLLTNLI RGNLLPSARL WITSRPAAAD QIPLDLVDVV TEVRGFTDVQ
     KEEYFRRRFR DEEQANKIIS HIQASRSLHI MCHIPVFCWI TATVLEDVVR TRGGGAEELP
     KTLTEMYVYF LVIQSKLINV KYHERSAADP HWSPENMKMI QTLGKLAFEQ LQRGNLIFYH
     SDLKDCGVDI KEASVYSGVF TQVFREERGL FQDKVFCFVH LSVQEFLAAL HVLLTFIKSG
     VNLLVEQPPR SLMEQPPRSL VPKLFRDKPE LRHLHRSAVD KALLSPNGHL DLFLRFLLGL
     SLGDNQRLLR EVLTPTGCSS ETNQKTAEYI KKKIGRNLSA ERSINLFHCL NELKDGSLVE
     DIQQSLRSGC LSTEKMSPAQ WSALVFILLS SGKDLEVFDL KKFSASEEAL LRLLLVVKAL
     RDCNLSERSC ENLSSVLRSQ SSSLRHLDLS NNHLMDSGVE KLCAGLKSPH CCLETLLSGC
     LVTHKGCSSL ASALSSNPSH LRELDLSYNH PGHSGQKVLS DGLNGPHWRL ETLSYELELD
     SNTVNKYLKL SEDSRSVTNV ARALAHPDHP HRFDHWPQVL CRPALTGRCS WELRWSGDVL
     VSVSCGEIRR KGKGPESSFS HSHQSWSLSC SDVRGYSVRH AKKETYVHSP VVSHRVSVFV
     DVPAGTVSFY RVSSDSLLHL HTFSTKFSGP VYPGFWVSFN SSVFLV
//