ID A0A3P8V297_CYNSE Unreviewed; 406 AA.
AC A0A3P8V297;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Fibrinogen alpha chain-like {ECO:0000313|Ensembl:ENSCSEP00000008687.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000008687.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000008687.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000008687.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-
CC identical chains (alpha, beta and gamma). The 2 heterotrimers are in
CC head to head conformation with the N-termini in a small central domain.
CC {ECO:0000256|ARBA:ARBA00025974}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; A0A3P8V297; -.
DR STRING; 244447.ENSCSEP00000008687; -.
DR Ensembl; ENSCSET00000008779.1; ENSCSEP00000008687.1; ENSCSEG00000005543.1.
DR GeneTree; ENSGT00940000157467; -.
DR InParanoid; A0A3P8V297; -.
DR OMA; VHARSIQ; -.
DR Proteomes; UP000265120; Chromosome 1.
DR GO; GO:0005577; C:fibrinogen complex; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0072378; P:blood coagulation, fibrin clot formation; IEA:Ensembl.
DR GO; GO:0070527; P:platelet aggregation; IEA:Ensembl.
DR GO; GO:0030194; P:positive regulation of blood coagulation; IEA:Ensembl.
DR GO; GO:0051258; P:protein polymerization; IEA:InterPro.
DR Gene3D; 1.20.5.50; -; 1.
DR InterPro; IPR037579; Fibrinogen.
DR InterPro; IPR012290; Fibrinogen_a/b/g_coil_dom.
DR PANTHER; PTHR47221; FIBRINOGEN ALPHA CHAIN; 1.
DR PANTHER; PTHR47221:SF3; FIBRINOGEN ALPHA CHAIN; 1.
DR Pfam; PF08702; Fib_alpha; 1.
DR SMART; SM01212; Fib_alpha; 1.
DR SUPFAM; SSF58010; Fibrinogen coiled-coil and central regions; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..406
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018106087"
FT DOMAIN 40..189
FT /note="Fibrinogen alpha/beta/gamma chain coiled coil"
FT /evidence="ECO:0000259|SMART:SM01212"
FT REGION 262..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 135..169
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 266..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 45134 MW; 9AAD074A4EC01FA2 CRC64;
MRKLHALVSL ILLCGAAASE LGPRGARPVE PSTRSDNCPP QKEWPFCTDD DWGHKCPSGC
RIQGLMDKND HMFLKGIEKI RNMLEQNQAK YRTTDHVSKQ TYDYLREKLT LESGWKKILT
NKYISFLFSN LRKRINDLKI TIDRQLRSLK ALKDRVRDQV VDMQRLEVDI DIKLRACKGS
CSNYPEYQVD RDSYVDLEKQ VNQLHSQAAQ SVETVKTLYV MKSRQLQDLT SDSNYKSGVT
KTAAQQKVDV KQFQLVLEEE GSKASPATIS KDTGTSFFPS SSSTSTTIVV HTKDGPVERT
EEVIEGGPQC QALADFTKGG SLPSTFSHTS SSSSSTTKTI HSGGTKGSLT TDSNTGFGDV
GFDLGGFMTD DPEDDIPDFH ARSVKSTRVE RQASYVGKGT ETSDVE
//
