ID A0A3P8V2L1_CYNSE Unreviewed; 843 AA.
AC A0A3P8V2L1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H3 {ECO:0000256|ARBA:ARBA00039924};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000008324.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000008324.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000008324.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May act as a carrier of hyaluronan in serum or as a binding
CC protein between hyaluronan and other matrix protein, including those on
CC cell surfaces in tissues to regulate the localization, synthesis and
CC degradation of hyaluronan which are essential to cells undergoing
CC biological processes. {ECO:0000256|ARBA:ARBA00037051}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
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DR AlphaFoldDB; A0A3P8V2L1; -.
DR Ensembl; ENSCSET00000008410.1; ENSCSEP00000008324.1; ENSCSEG00000005291.1.
DR GeneTree; ENSGT00940000154554; -.
DR Proteomes; UP000265120; Chromosome 11.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF115; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 25..154
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 280..463
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 843 AA; 94533 MW; D9A7493BC387F17A CRC64;
VNKQIFISLP LPMYIHVTSP GFKRSSKLDS HFLLFFQMVE VQSVKIACAV MSRFARTVMT
SIALNKANSS QEVFFKVELP KTAFISNFSM EIEGQVYVGQ VKGKEKAKQE YDKAVSSGKT
AGLVKASGRK MESFSVSVNI AAKSTVTFVL TYEELLQRKL GKYEILTRVQ PKSLVQDFQI
VADIYEPQGI SFVDATATFL SNDLLPLVKK TVSDKKAHIS FSPTVEQQRN CSGCEATIID
GDFIINYDVR REAGLGEVQI VNGYFVHFFA PPDLHRVPKN VAFVIDRSGS MSGTKMKQTR
DAMVAILKDL HEEDHFALIL FDDNIKTWKN HLTKATKNNI TEAIEYTQGI RDSGATDINR
AVLKAVEMLK KERSQDKVPK RSTDMIVLLT DGMPNSGVSN LGKIQENVRS AVGGNMSLFC
LGFGNNVDYS FLDVMSKQNK GLARRIYEAS DATLQLQGFY EEVASPLLLD IDLRYPDNAV
EFSTKNSFTH LFNGSEIVVA GRLHDNSVDN FLVEVSGEGV RRTNTSVGML DGTNLEEERM
RFRYFKNIDY VCSQRKNVNM KEIIQEEVQK SSLNVSFNHW KNVNGGSSLF LQSEKNYQVQ
GKPVGCGVAS CLTSSQCNCD DASTVDGDPH FLIEVPDRDD ALCFTITDKP GTIFSLVRDP
KSGFVVNGQI IGVKGRNNNT YFGRLGIINL CDGRESCKIC VPHSELKTKP MSYRLNVTLR
HFIKFVIVKH TKMWKRRHDQ QDYLGFYTVD SHHVSKTVHG LLGQFYHEVK FEVEGLNPQE
VQEKEDAFLH FKGQTIKVSR HIQKDFSKDV VNGEKVPCWF VDSSGSGLVD GQLSDYVLSG
LFD
//