ID A0A3P8V2Y1_CYNSE Unreviewed; 1137 AA.
AC A0A3P8V2Y1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=NACHT, LRR and PYD domains-containing protein 12-like {ECO:0000313|Ensembl:ENSCSEP00000008927.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000008927.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000008927.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000008927.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8V2Y1; -.
DR STRING; 244447.ENSCSEP00000008927; -.
DR Ensembl; ENSCSET00000009024.1; ENSCSEP00000008927.1; ENSCSEG00000005712.1.
DR GeneTree; ENSGT01100000263513; -.
DR InParanoid; A0A3P8V2Y1; -.
DR OMA; CNLSWRI; -.
DR Proteomes; UP000265120; Chromosome 14.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006574; PRY.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF13765; PRY; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SMART; SM00589; PRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 305..439
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 926..1137
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 16..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1137 AA; 127983 MW; FDD18F0823DF6C42 CRC64;
MCLSLVESKL RIMNQGEDSE NGIPVTESTT LCQGHGSQPE VQRNHLKEQS SLCGPKPLPS
SVSCKSNQSM ELPLCFAKNK PTSSDSGIEC EPSCMSLKSN QSMEPPLCFA KNKVNEECLV
DPSGQPCQQL QAKLDSVFAL LENNMFTFVK SELRKMQKVL MSDSPDCSEV GVEVKAEDAM
DDELGRSNRE AVLKLTLNFL RMMNKEDLAD CLQSGSRAPL CQSKLKSNLK RKYQCVFEGI
TKAGKPTLLN QIYTDLFITE GDAGEINEEH EVRHIESASR KLGKEERTIR EEDIFKVSPG
RDRIRTMLTK GVAGIGKTVL TQKYTLDWAE GKTNTDIQFI LPFTFRELNL LKGKQLSLVQ
LIHHFFTETK EAGISRFEEF QTVLIFDGLD ECRFPLDFRN TELVSDPSVS ASVEVLLTNL
IRGKLLPTAR LWITTRPAAA NQILDQFIDM VTEVRGFTDP QKEKYFKNRF QDTDKANKII
SHIKASRSLH IMCHIPVFCW ITGTVLENML KTKHKGDLPK TLTEMYIHFL VVQSKLKVVK
YDEGSPTDPH WSPESMEMIK SLGKLAFEQL KKGNLIFYDS DLRDCDIDIT AASVYSGVFT
QIFKEEQGLY LDKVFCFVHL SVQEFLAALY VHLTFINLGL NLITQEKSNL PLSALAKKQF
YHSAIEEALR SHNGHLDLFL RFLLGFSLKI NQSLLHGLLT NTGIYLSTSQ ETINYIKKKI
EETTSAETSI NLFHCLNEVN DRSLVEEIQQ YMESGSLKEG KLSPGQWSAL AFILLSSAED
LNVFELKKYW ASEAALPRLL PVVKVSTKAL LNDSNLSERS CKALSDIFSF KSSALKYLDL
SNNNLQDSGM KLLSVGLQSP HCVLETLRLS GCNLSERSCE DLALVLSSES CSLRDLDLSH
NNIQDSGLKL LSVGLQSPHC VLETLRVEPE GVRWLRQGLK KYFLVNTFDP DTVHPNISVS
KDGRTVTYVE DPQPYPDLPE RFDQRTQLLC ANPLAGRCYW EVDWDGIVCI ALSYKGVGRK
GDEEDCWFGR NPQSWALYCC NLDYFSFSHK TKDICAQGKY LAYHDNNLTT SSITSSFSCP
NKGAVYVDCP GGTVSFFVVS SDTLIHLHTF NTTFTEPLYA GFGFWRWINN SISLTSS
//
