ID A0A3P8V2Y5_CYNSE Unreviewed; 1505 AA.
AC A0A3P8V2Y5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Nuclear factor of activated T-cells 5-like {ECO:0000313|Ensembl:ENSCSEP00000008932.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000008932.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000008932.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000008932.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_008310183.1; XM_008311961.2.
DR Ensembl; ENSCSET00000009030.1; ENSCSEP00000008932.1; ENSCSEG00000005716.1.
DR GeneID; 103380139; -.
DR KEGG; csem:103380139; -.
DR CTD; 334390; -.
DR GeneTree; ENSGT00940000155213; -.
DR InParanoid; A0A3P8V2Y5; -.
DR OMA; LPMGQQS; -.
DR OrthoDB; 5405363at2759; -.
DR Proteomes; UP000265120; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd07882; RHD-n_TonEBP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR015646; NFAT5_RHD_DNA-bd.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF10; NUCLEAR FACTOR OF ACTIVATED T-CELLS 5; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 294..461
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 34..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 829..952
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 36..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1079
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1505 AA; 163529 MW; F3EFF0D9D584E229 CRC64;
MPSDFISLLS SDLDLNSPKS LYSKESVYDL LPKELQLQLS PSQTDPPTMS QKSGGEPGPP
LPAALASDAT SSTSSPSASS CLDMGAPSTG PSTSSPDHLK VPQLLHSIGG EGAGPSEMKG
LESAVSGSSR GNGGTSGAAG DLGSGVLSGI AVPQPQNMPS KRRPVLSISP PPEDLLDDSQ
MSCQEEPVAP LGPESEHSSS MWADDSVSNF SVVSSISYND NTEVPRKSRK RTPRQRPGPK
SDPPEDSMDV FDADSAKAPH FVLSQLGTDK TGPSSFEAVP ASKSGSLSAQ FPCRSDGKEL
KILVQPETQH RARYLTEGSR GSVKDRTQQG FPTVKLEGVN EPVVLQVFVA NDAGRVKPHG
FYQACRVTGR NTTACKEVDI EGTTVIEIPL EPSSDMTLAV DCVGILKLRN ADVEARIGVA
GSKKKSTRAR LTFRVNIPQS DGSTLTLQVP SSPILCTQPA GVPEILRKSL HICSVKGGEE
VFIIGKNFLK GTKVIFQENI ADDNSWQAEA KIDMDFFHQN HLIVTVPPFH NQSITSPVPV
GVFVMTNAGK SHDAQPFTYT PDTADNSNVQ SVKSEGPSLV KTCIFDGQMK SLSTEQTDCS
GQPCKQEDTP MEVSNNPSLT DVYKPSPDPL VSVQQTLELN SSPHQGGESF QSPVPLQPED
VELPQAPSVF PSLETLNTIQ KQDITSTTSF PVSGDTTIPP VTPEVPQQFL REPQDNLPPE
NSNNGGGIVV VTMPQISSPS QPQTQQSEVP LFPQEGVAQL ERAVRELQAG GNTAFQQVLE
AAVAQQQLNS VLYSPPPTAD SLQQHVQENM NSLRLGTTDN SLSTQQQLQM EQQQQMQQQF
QQHQQLQQQQ QILDNIQHQQ QQQQQQVLGN MQMQQQLLLQ PQDQQQLQQQ QQQLMENIKQ
LQQNQQQHVL NIQLSDQQQQ SQILTNLQHH QLQQQQQQQS QALSNIQQQQ QLQQSQQQHG
LNIQLPDQQQ QNQILTNLQH HQLQQQQQNQ ALSNLQQQQQ FQEHQVLENL QQQLQAELMQ
PQMNSTSQVQ QPVSLLQQAG ELLTIQTSFP TPPPTHTSPP QQLFQSPRPL AETQSPQQQV
QAALLQNTLT VLTCGSLGSD QQPPGSALYL SPNPPQQQQQ LAFISSMETS ANPSQTVTMF
QNQPQTQLSQ MQQQSTPMDQ QHSPQQSQQP PPQLTIGQQR TLFQSIPNHS QNNPVPQSQL
SQSQQTDLLL CSTNLNAQTI SSTLLFSTQT QGTSPLGDIT GGISQPEPAE PMSFQDQSSS
GSTSAPLENR QQNLFQEQQP MQVGPSPSSV QNSQPVELFL PSTSLSGLQS TIGTQEQNNP
TPAPGTTIFV VQGGIGVVAS TAQQPPEQLF QTPVGGNSQA QANLFVYGIQ NESTQMHGSV
RPSLPTQHQT QNSGHMQPLL DQPMSQAASS MPVSLHSSLQ NTLQAQIQSS LDNALQSSLQ
NAMQTDTQTS LQSTLQASIE TSLPTPMQTS LESEMQSLQN QLEASISAAS NMDKIEDLLE
SLQKS
//
