ID A0A3P8V3P3_CYNSE Unreviewed; 698 AA.
AC A0A3P8V3P3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSCSEP00000009202.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000009202.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000009202.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000009202.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR AlphaFoldDB; A0A3P8V3P3; -.
DR Ensembl; ENSCSET00000009311.1; ENSCSEP00000009202.1; ENSCSEG00000005847.1.
DR GeneTree; ENSGT01070000253775; -.
DR OMA; GIFECIM; -.
DR Proteomes; UP000265120; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF196; SOLUTE CARRIER FAMILY 26 MEMBER 6; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 91..109
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 173..200
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 245..269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 370..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 408..427
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 466..497
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 521..682
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 571..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 76385 MW; 0C337EE9FAA06A99 CRC64;
MMAIRGMDYV IHRRILDEET VDEIGAKFES NIPLSEKVKR ALRCSVPRLK KCLLQRFPLI
KWLPHYPIRE TAIGDLISGI NGGIMQIPLS IAYAMIAAVP PVFGLYAAFY PMLVYFIFGT
SHHLIIGGYT VLALMMRGLG DRLAPDSDFM IWDNETNSSV VDTVSQDAKR VQVVVAVTLL
SGLFQILLGL VQFGVMVTYL SEPLVRGYTT GATFHIFMSQ FGNIFGVTYV RHNGPLMLPK
NFIEFLFVLH VTHIPTLVVF VVAMVGLVVA KRVSEFLSKK LPVPVPVELL AVIISTLVSW
KLNLNESYKI AVVGNIPSGL QPPSLPPTSL IGEVIGDAFA MAVVGYGMAI SLGQVFALKH
GYKVDSNQEL IALGLSNAVG GLFQSIAISG SIPRSLVNES TGGKSQVLAG AVSAIVILIA
LFSIGSLLSD LPKAVLAAII FVNVTGTLKQ FHDIPALWKT SKVDMFIWLA TFIFILLLNP
DLGLPAAIGF SMLTVIFRTQ RPKYSLLGQV QGTDIYRPFE NYSQVKAVPG IVIFRSSATL
YFANADMYKN ALSKKSGLDV HKILATKKKQ EAKRQKLQKE NAKRTNGEGK EEGGVIIDVD
PEPFPSIPRA IILDLSPVNF LDTVGVKALQ NIYRDYGKIG IEVLLAGCQT GVMDQLKIGG
YFSDKVTKSC VFSTIHDAVL YCQPVRRTAE VILWSVNM
//
