ID A0A3P8V5N0_CYNSE Unreviewed; 671 AA.
AC A0A3P8V5N0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 {ECO:0000313|Ensembl:ENSCSEP00000009862.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000009862.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000009862.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000009862.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8V5N0; -.
DR STRING; 244447.ENSCSEP00000009862; -.
DR Ensembl; ENSCSET00000009976.1; ENSCSEP00000009862.1; ENSCSEG00000006320.1.
DR GeneTree; ENSGT00390000015298; -.
DR InParanoid; A0A3P8V5N0; -.
DR OMA; GLVHFMY; -.
DR Proteomes; UP000265120; Chromosome 12.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR026053; HPS1.
DR PANTHER; PTHR12761:SF1; HERMANSKY-PUDLAK SYNDROME 1 PROTEIN; 1.
DR PANTHER; PTHR12761; HERMANSKY-PUDLAK SYNDROME PROTEIN 1; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 2..158
FT /note="FUZ/MON1/HPS1 first Longin"
FT /evidence="ECO:0000259|Pfam:PF19036"
FT DOMAIN 204..360
FT /note="FUZ/MON1/HPS1 second Longin"
FT /evidence="ECO:0000259|Pfam:PF19037"
FT DOMAIN 511..664
FT /note="FUZ/MON1/HPS1 third Longin"
FT /evidence="ECO:0000259|Pfam:PF19038"
FT REGION 249..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 76311 MW; 2090542948198061 CRC64;
MRCLLIASES AEVLFHWTDP EFQQSIQQQY GSSQEDGHGL PAFEDSISTL FAPIIISCST
MVDRLGDGYT SFTTENNHIY ALHQFDECLY IAVNGDGEED EDVLRRKIYV MKKMIEVLFG
MVTLSSQLLR RELRPQDTEQ RARLWKHLQG LLETYSHLRE NDQSFLVEAV ERLIHPTLCE
QCIEFLERRL VQQLNSSTEK AGEEVLHAFI LVHTKLLAFY SSRNASTLAT SDLLALIIVA
QNMYPSSVDL DDSSPEVRTS SGPESFYTPE PSPTDRTSMK RGNTPVFEFM DPDVQMAEDS
LQALDVPAPD PSTPRRVFLE ISSKDGLYAM MPHSMYCLPL WPGITLVLLT KIPTSAVAMS
IYKFLEAFTK LEKCLGEGQD SSAASRGQLA IHDIRSKLDK FIKALGPSEL QSAQLLNVWT
EFKNRAFVRG GSGFNKDLLP WCTRMKTQLC GIYRQCFLSP CGPGDVTQRL SSSLQERAQT
MVQEKLMDWR DFLLVKSKRN ITMVSYPDFP GLIHFICVDR STGQMIAPSL TITERTTSEL
GKGPLAQFFK NKVWSLVSTT RCFLRKGYST VTLRDGDFYF CYFLWFENDT GYKLEAGDLP
ILPDDSAPIG MLAWDYYRKL QRYYSKSHQG EVVRCYELLT VHLGVIPTEI ILQHCRQLAS
KLWEPSRNPL L
//
