ID A0A3P8V5N4_CYNSE Unreviewed; 541 AA.
AC A0A3P8V5N4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Golgi associated, gamma adaptin ear containing, ARF binding protein 1 {ECO:0000313|Ensembl:ENSCSEP00000010708.1};
GN Name=GGA1 {ECO:0000313|Ensembl:ENSCSEP00000010708.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000010708.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000010708.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000010708.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR AlphaFoldDB; A0A3P8V5N4; -.
DR STRING; 244447.ENSCSEP00000010708; -.
DR Ensembl; ENSCSET00000010837.1; ENSCSEP00000010708.1; ENSCSEG00000006865.1.
DR GeneTree; ENSGT00940000156448; -.
DR InParanoid; A0A3P8V5N4; -.
DR OMA; SAPSQEM; -.
DR Proteomes; UP000265120; Chromosome 17.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd17009; VHS_GGA1; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905:SF4; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50179; VHS; 1.
PE 4: Predicted;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 17..147
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 412..533
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 257..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 541 AA; 59789 MW; B259B58AEBB38A2A CRC64;
MAAPPDAESL ESRINKATNP LNRETDWSSI HAFCDQLNNE LEGPQLATRL LAHKIQSPQE
WEAMQALLVL ETCMKTCGKR FHSEVGKFRF LNELIKVVSP KYLGSRSPEP VKKKVLELIY
SWTLGLPEEI KISDAYQMLK KQGIIKQDPE LPPDKLLKLP PSRPKNAIFE DEEKSKVSLL
KLYLKKMFEM VQEDQRRAEK VSKRVNAIQE VKESVSLLTQ LLQEWDSNAS DQSNAELLQK
LRPTLFRLAS DTEDNDEALG LSEGTHTSNP HSQPEDSTAW DSFQSSESID ADVAAAPSLL
LSPDPPSLSQ PLSSGSTPGN SALDELDLLG KTLLQQSLPP EGLQVKWDKH QSKPTLRDLQ
SKTSSHITPN PIPTFSSEPA APQLNSQPGL GTAPTEVSLT DVFIPLESIK PSNLLPVTVF
DKHSLRVLFH FARDSPPSRP DVLVVIISML SSAPVPVSNI NFQTTAPKSM AVKLQPPSGT
QLSAFNPILP PAAITQILLL ANPNKEKVQL QYTLTFTMGE QERTESGSVE EFPSPDTWGS
L
//
