ID A0A3P8V5S9_CYNSE Unreviewed; 1479 AA.
AC A0A3P8V5S9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2-like {ECO:0000313|Ensembl:ENSCSEP00000009454.1};
GN Name=MAGI2 {ECO:0000313|Ensembl:ENSCSEP00000009454.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000009454.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000009454.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000009454.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR Ensembl; ENSCSET00000009566.1; ENSCSEP00000009454.1; ENSCSEG00000006043.1.
DR GeneTree; ENSGT00940000155057; -.
DR Proteomes; UP000265120; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 6.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 6.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF78; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 2 ISOFORM X1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF17820; PDZ_6; 2.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 6.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 6.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 6.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT DOMAIN 17..100
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 89..145
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 271..304
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 317..350
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 395..464
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 589..654
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 752..842
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 898..988
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1170..1252
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 137..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 987..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1319..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..708
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1080
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1479 AA; 159473 MW; E51D3225956AA8A3 CRC64;
MSKSLKKKNH WTNKVHEAVI TRGKDGEMGF ELKGGAENGQ FPYFGEVKQG KGLIQSGKLA
QDELLLEVND MPVAGLTTRD VLAVIKHCKD PVRFKCVKQG TTRQPKEGEV PGVDYNFVSV
ERFMELEQSG ALLESGTYED NFYGTPKPPA EPSPAAPPLN VSEALLPGAR PSAQGKRKRN
QSVSNMEQRA SLEPPEEEEE ESPVVNGNGV AITPESSEHE DKSTDASGEV AVDVSSQAPA
SIEVNTEGEE APSSPPKSPG KVPDADEEEL GPLPDNWEMA YTEKGEVYFI DHNTKTTSWL
DPRLAKKAKP PEECREDELP YGWEKIDDPI YGSYYVDHIN RRTQFENPVV EAKRRLEQQR
QIQSQGLSAL PLPTIYREKS LFTRDPTQLK GTFLSTGLQK SNMGFGFTII GGDEPDEFLQ
VKSVIPDGPA AQDGKMDTGD VIVYINDICV LGTTHADVVK LFQSVPIGQS VTLVLCRGYP
LPFDPEDSSG AAGTSLTPIG MEHCPLVVNG RSSYDPYLEY LSLSSQLPPQ ALAQAGAHHP
GDTHLDGSSL PPTTPGSASA LTPHDDVSMA SSGTAGVTGT TAQGAELLTV TMVKGAEGFG
FTIADSPTGQ RVKQVLEPGS QGASGLIEGD LILEVNQQPV AAAGHGQVVD MLKECPVGAE
ATLVIQRGTG HISPWKASKQ LTDHWDPHGS PQPHLSGPVL PPGTPFPNQP QHRTSVPDST
EGFDLIKPDP YDLYEKSRAI YESRRPEYEE VEVHLLREKT GFGFRILGGD EAVQAVSPDA
RDKIVIGAII ENTPAERDGR LRPGDELISV DKNVVAGQPH KYVIDLMHAA ARNGQVSLTV
RRRVQAPGEP CPVNGRSPGP VSAQHSSPHS DAASALASAA AAAAATSPAE GSALQTSDVV
IHRKENEGFG FVIISSLNRP ENATVITVPH KIGRIIEGSP ADRCGKLKVG DRILAVNGQS
IISMPHADIV KLIKDAGLTV TLHIIPEEGS QSGPSSEKQS PMTQKHSVQT QPSPVAQPNQ
GGAQPGQTAP QPGQTAIHTS QAPAQPGQTV TQTNQTVTAS AAPHPAPAGN QQSPVSQPSG
LPPQLYLHDG RSEVKARQDV KPDFRHPPFT DYRQPPVDYR HPPITDYRQP PTLDYRHPPG
LLDFRQHPAA AQFPLGISTD FRPQDFDYFT VELEKSAKGF GFSIRGGREY KMDLFVLRLA
EDGPAIRNGR MRVGDQIIEI NGDSTREMTH ARAIELIKAG GRRVRLLLKR GTGQVPEYDC
SGPWDYLSTA HPAMQEVTFE PHPNPLRSSL DFPHQLHLEA TVCMADKALQ LTEHGSIRGA
IGGRSTQQKS LVRGQGTPQG PAEVDCVASN EQPLALPPKA VLGRSTETRE RQKETCSPCC
DKKVLHTQAM SAIWPWDAYI SVNSNEAPPA GGEGHVGLQE RLVSRGSLSR EEERTSGHGG
LCCPSKILDD PAASPAPWSV PESYKLPGTL RSWTSTVSR
//
