ID A0A3P8V7G1_CYNSE Unreviewed; 627 AA.
AC A0A3P8V7G1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Leucine-rich repeat transmembrane protein FLRT1 {ECO:0000313|Ensembl:ENSCSEP00000009141.1};
GN Name=FLRT1 {ECO:0000313|Ensembl:ENSCSEP00000009141.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000009141.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000009141.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000009141.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8V7G1; -.
DR Ensembl; ENSCSET00000009249.1; ENSCSEP00000009141.1; ENSCSEG00000005865.1.
DR GeneTree; ENSGT00940000159375; -.
DR OMA; QDNGMTH; -.
DR Proteomes; UP000265120; Chromosome 15.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF15; LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01463; LRRCT; 1.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 474..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 381..474
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 627 AA; 68621 MW; 22180BDD291C97AA CRC64;
TQSYDGIVCP SVCRCDEGFV YCNDRGLSLI PPLPLMAAIL YLQSNRLTNA GLPPSLERSN
SIRVIYLYAN QLDEFPIHLP PSLRELHLQD NNIRTLPRSA LAKLPLLERL HLDDNSISTV
SIQDRAFSGT PRLRLLFLSR NHLSSIPAGL PASLEELRLD DNRISTIPTH AFRGLSSLRR
LVLDGNLLAN TRIADDTFSR LSNLTELSLV RNALQSPPVK LPTAHLIRLH LQDNGLTHIP
RGALDGMRRL QKLDLSGNNL TSLPRGLLKD TESLEMLLLR GNPWYCGCNL RWLHAWLHGR
GSGVTVRGLT CQGPEAVRGQ SLKDLTSLME QCETGASVPH GITTTPSLLI PTQGSLFTLR
AKWPDLVMPL PPSEGGHVSG EALELTVKHL SSDSVLVSWL CPKPAPSFRL SWLRLGSSAA
LGSITETLVP GERTQYLLNQ LTPRSHYLIC LLPLRQDHPF GGPSMGTSRT GSSALPLAGI
IGGATALVSL LLIFGIFCWY GQRAGYMSGD SGSYNRGRGG KHYDDYVESG TKKDTSILEI
RAPPPGFQMT AMTHQPLQPK LEDVTYIHTI FPSSSSSSQA NGTYRSNHVA GSLNGTILSQ
TSHHHVTYGT NRGYRDGGIP DIDYAYT
//
