ID A0A3P8V7R8_CYNSE Unreviewed; 1215 AA.
AC A0A3P8V7R8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Neural cell adhesion molecule L1-like protein {ECO:0000313|Ensembl:ENSCSEP00000008455.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000008455.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000008455.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000008455.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR AlphaFoldDB; A0A3P8V7R8; -.
DR Ensembl; ENSCSET00000008544.1; ENSCSEP00000008455.1; ENSCSEG00000005372.1.
DR GeneTree; ENSGT00940000165371; -.
DR Proteomes; UP000265120; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF51; NEURAL CELL ADHESION MOLECULE L1-LIKE PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1215
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018078728"
FT TRANSMEM 1087..1111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..122
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 129..213
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 246..328
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 338..425
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 431..514
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 522..615
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 622..718
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 723..816
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 821..923
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 924..1025
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 62..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1189..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1215 AA; 134051 MW; 0949240C31C9F2A8 CRC64;
MRLTGTLQLA LLLALTYRAV GLSIPLEVEQ PPTIINHTSG PIIALPFDNF ITIRCEAKGN
PPPEYRWTKD GKDFEPPHMT TSDSDRTDGK MVLSYKNLIH FQGKYRCYAS NKLGTAMTEE
IQLIVAANPK FPKEEIDPLI VQEGEPIVLH CTPPEGVPPR QIYWMTIGLQ HIEQDERVSM
DVNGNLYFSY ALRKDSRPDY CCFVAFSRIR TIAQKTAMAV IVQSLNSDNE TADSSDAIED
HPVRKPGLLL PSGVQSEKVL LKGADLQLEC IPQGFPNPTV TWRKLGEELS PRKKFNNFGK
LLTIPAVQES DQGKYMCTAK NPAGEAVHYF DVIVEEPPKW LTEPPQSQLA VIGSDVHVKC
SVSGKPPPDI TWRRNGERIQ DDPGSNRRVL DDTMILHRAT AEDSGVYQCE ASNSHGSVMA
NVNIMIMNTA PQILTRDFQT YPVILEGNVT MNCSVFSSPP PTISWARDDS AETVKEERFF
PLQNGSLQIS GAEKGDSGEY VCTAFNTEGE SSVTAVLEVK DPTKIVSPPE DMQVVSGTTA
QLMCRADYDR SLQSTFEVVW TKNGEEIPLP TEEHSRYFVE DGTLQIMSVN LTDEGTYSCT
ARTSLDEDSA TAYVTVLDVP DAPKNLQVSE ATNPRNVVLT WVPGIDHNSS VTEFVVEYEE
SQWDPGRWKK LQKVAGNQAT VELALQGHIN YQFRVYALNA VGPGPPSEPT ERYKTPPAAP
DRNPENIKIQ GVLPHQMDIT WEPLMPIEHN GPGLEYRVSY RRLGVDDQWK EHMVKRHSFV
VKNTTTFVPY EVKVQSRNSL GWGPEPKVVT GYSGEDVPTS APKNVAVEVV NSTILRVSWT
PVPAATVRGH LGGYIVHWSR RRSLLDPNRI LDIHQSLSFP GNRSNTEVPG VKPFSEYTLT
VNVYNKKGNG PSSDPVTFNT TEGVPGLVPV LTASNAQRDS ILLVWGPPLE TNGVLTGYLL
QFHLLNETSR EMADSQEVNI TGPDTTQWQL QGLEQGSLYS FRLSACTRAG CGLPLAQESS
TVTAGHLSLT PAVAPVQSIP VLLNVSTYVS DTFANISWTT TDPQQDSQLY VAHVNNRVEG
QQRDPSIHGW VIGTMCAVAI LTLVALMACF VRRNRGGKYS VKEKEDLHPD MESQGMNDDT
FCEYSDSEEK PLKGGSLCSM NGNDTAGDSV SRDSLVDYAD GGREFDEDGS FIGEYSGHRH
AGSVSEPSGF TPVNA
//
