ID A0A3P8V7T5_CYNSE Unreviewed; 856 AA.
AC A0A3P8V7T5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Semaphorin 3C {ECO:0000313|Ensembl:ENSCSEP00000011408.1};
GN Name=SEMA3C {ECO:0000313|Ensembl:ENSCSEP00000011408.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000011408.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000011408.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000011408.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; A0A3P8V7T5; -.
DR STRING; 244447.ENSCSEP00000011408; -.
DR Ensembl; ENSCSET00000011549.1; ENSCSEP00000011408.1; ENSCSEG00000007345.1.
DR GeneTree; ENSGT00940000159379; -.
DR InParanoid; A0A3P8V7T5; -.
DR Proteomes; UP000265120; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd05871; Ig_Sema3; 1.
DR CDD; cd11251; Sema_3C; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF25; SEMAPHORIN-3C; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..856
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017987976"
FT DOMAIN 131..614
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 693..758
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 810..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 96266 MW; 6C0D12F8CE2E63B0 CRC64;
MLSFIVFVDT FSMATVCNGG SRAANTDQRF QLSTSLHGAP GENAGGDGTL CVFIHSSFGL
GISGQFYWDY CCWTCLQRES SDQSSILSGA VMGRPEGLAR PPLVSTMELS LLALCLFVST
GVSSLPQPVP RVSLSFDDLQ ASHSFEHYSI SDKAMDYRIL HMDEDQDRMY VGSKDHVLSM
DINNITHGTL KVFWPASPSK IEECQMAGKD PTHGCGNFIR VVQPYNRTHL FMCGSGAYSP
VCVFINRGRR PEEQVFHIDS RTESGKGRCS FNPQVNTVSV MLNQELFSGM YIDFMGTDAA
IFRSLTKQNA VRTDQHNSKW LSEPNFIDAH LIPDGTDPND AKLYFFFRER LTDNNGNTKN
IHTMVARVCP NDIGGQRSLV NKWTTFLKAR MVCSVLEEDG TETHFDELEN VFLLETEQPK
SLLVFGVFTS TSSVFKGSAV CVYNMADVLT VFNGPFAHRE GPNFQWTAFQ GRIPYPRPGT
CPGGAFTPDI QTTKEFPDDV VTFVRNHPVM FNPIYPVGRR PLVVRTNAEY RYTSVAVDQV
MAADGNYQVL FLGTDKGTIQ KVIVLPSNHS LQEDLILEEL EVFKDQAPVT NLRISSKKQQ
LYVSSEFGVS QVSLHRCHAY GSACADCCLA RDPYCAWDGL SCSRFYPSNK RRSRRQDVMH
GNPLTQCRGF NLKAYRNAVE MTQYGVKNNT TFLECLPKSP QASIRWLIHR DNDRRKEVKL
SERVLSTEQG LLIRSVQLSD QGLYYCLTTE NGFKRTVAKI RLRVLSEAMV SVLMDKQQPW
AWASSLHPKA LLSAFSPAES MAVQQYCKER KELQKQQQPK QQQPQPPGPL RGDLAKLKPL
LDLRKSRNRR NHLPDV
//
