ID A0A3P8V974_CYNSE Unreviewed; 948 AA.
AC A0A3P8V974;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Protocadherin alpha-10-like {ECO:0000313|Ensembl:ENSCSEP00000009791.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000009791.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000009791.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000009791.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8V974; -.
DR Ensembl; ENSCSET00000009905.1; ENSCSEP00000009791.1; ENSCSEG00000006284.1.
DR GeneTree; ENSGT00940000164173; -.
DR Proteomes; UP000265120; Chromosome 15.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF287; CADHERIN-RELATED NEURONAL RECEPTOR VARIABLE 1-RELATED; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..948
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018157340"
FT TRANSMEM 690..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..132
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 133..240
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 241..348
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 349..453
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 454..563
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 570..675
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 868..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..921
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..936
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 948 AA; 103783 MW; F858C9B4E666F6B6 CRC64;
MSSICRRKYL GICLWFLLLN FYWETVCGQL SYSVSEELKP GSSVGNIAKD LNLNPQDLEY
RKFQIVTGSK RKFFEVNLKT GVLYVSERID REELCAEELK CTLSVEAVIN NPLKLYRIDV
DILDVNDNAP LFTTDLQHLH IAESTLPGVK FALSEATDAD VGKNAVSTYK LSQNEHFSLA
VHKSGDGVSA ELVLQKAVDR EKQPVVTMTL TAVDGGSPPK SGTSKIIIHV LDNNDNLPIF
SEALYKTKLL ENSPIGTTVI SVNATDADEG LNGEIVYSLR SKDQDRVLDI FEIESQTGVI
HVKDNVDFEE RKAFEIRVEA TDKGQPPMSA HCKVLVEVVD LNDNAPEITV TSLLNTVKED
TSVGTAVALV SVVDKDGGKN GEVNVHIENA APFKLDTNYK NYYSLIVDGP LDREAVSIYN
VTIAARDKGE PALSITSVVS IRVSDVNDNA PKFPESFINV YVNENSPVGK MMKSVTATDA
DIDQNSQLTY SILPNKDDLM HLSTMVNINS ETGDVTSLQA FNYEELKTFQ FKVQATDSGV
PPLSSNVTVN VFILDQNDNK PVILAPYSEH GSIYSETVPY NVEAGHIVAK IRAVDADSGY
NALLSYHLTE TKGNNLFRIG TSTGEIKTKR RMSDNDLKTH PLVIMVSDSG EPSLTATVSV
EVVVVESSAD IQTQFRHVPI KKDNFSDLNL YLLIAIVSVS AIFLLSLIVL IVFKCHRKDN
TFNGYGAPMI TTHPDGSWSY SKATQQYDVC FSSDTLKSDV VVFPPLYPQL DAELISINGG
ETFSGTQTLP NKEKPKAPNS DWRYSASLRA GGVMQSSVHM EESSVMQGAQ GVLVQNWPTV
SSAADGEGGE VSPPMGAGVD SNSWHFRYGP GGPGAPPQHL KPGEVPPEAF IIPGSPAIIS
IRQNQGGDDD KSDFITFGKK EEAKKKKKKK KEKEKKDKKD KGKDDGDE
//
