ID   A0A3P8V9A7_CYNSE        Unreviewed;       725 AA.
AC   A0A3P8V9A7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) {ECO:0000313|Ensembl:ENSCSEP00000009826.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000009826.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000009826.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000009826.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the ubiquitin conjugation factor E4 family.
CC       {ECO:0000256|ARBA:ARBA00007434}.
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DR   AlphaFoldDB; A0A3P8V9A7; -.
DR   STRING; 244447.ENSCSEP00000009826; -.
DR   Ensembl; ENSCSET00000009940.1; ENSCSEP00000009826.1; ENSCSEG00000006305.1.
DR   GeneTree; ENSGT00390000009300; -.
DR   InParanoid; A0A3P8V9A7; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000265120; Chromosome 10.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0034450; F:ubiquitin-ubiquitin ligase activity; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:InterPro.
DR   CDD; cd16658; RING-Ubox_UBE4B; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR019474; Ub_conjug_fac_E4_core.
DR   InterPro; IPR045132; UBE4.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13931:SF2; UBIQUITIN CONJUGATION FACTOR E4 B; 1.
DR   PANTHER; PTHR13931; UBIQUITINATION FACTOR E4; 1.
DR   Pfam; PF04564; U-box; 1.
DR   Pfam; PF10408; Ufd2P_core; 1.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS51698; U_BOX; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT   DOMAIN          649..722
FT                   /note="U-box"
FT                   /evidence="ECO:0000259|PROSITE:PS51698"
FT   REGION          480..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   725 AA;  84967 MW;  109A13D762EBB83A CRC64;
     MHFQLKCSFM FCFGFFFIQM FRVKWETSIS LALPSLWRTP ELSVSRCSTT WNWRGVTCLK
     FSTISCCMES REAETRDLAL NYMAALVNYN VKKAQMQTDD KLVSTDGFML NFLRVLQQLS
     MKIKLETVDP YYIFHPRCRL AVSVEETRLK ATMEELKSWL SELHEDPSKF SEPKFPTECF
     FLTLHTHHLS ILPCCRRYIR RLRAIRELNR TVEELKNSEG QWKDSPLASR HREMLKRCKT
     QLKKLVRAKA CADVGLLDEN LLRRCLQFYS TVIQLLLRMV DPAYPNITLP LNPEIPKSFA
     ALPEFYIEDV AEFLLFVVQY SPQVLYEPCV QDIVTFLVVF ICSQNYIRNP YLIAKLVEVL
     FVTNPAVQLR TQQFSEMMEN HPLSIKQLVP ALMKFYTDVE HTGATSEFYD KFTIRYHIST
     IFKSLWQNIA HHGTFLEEFN SGKQFVRYIN MLINDTTFLL DESLESLKRI HEVQEEMKNK
     EQWEQLPRDQ QQSRQSQLTQ DERVSRSYLA LATETVDMFH ILTKQVQKPF LRPELGPRLA
     AMLNFNLQQL CGPKCRDLKV ENPEKYGFEP KKLLDQLTDI YLQLDCARFA KAIADDQRSY
     SRELFEEVIS KMRKAGIKSS IAIEKFKLLL EKVEEIVARN SQSEMDYSDA PDEFKDPLMD
     TLMTDPVLLP SGKIMDRSII LRHLLNSNTD PFNRQPLTES MLEPVPELKE RIQAWMREKQ
     GGRLV
//