ID A0A3P8VAE7_CYNSE Unreviewed; 229 AA.
AC A0A3P8VAE7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Spindle and kinetochore-associated protein 2 {ECO:0000256|ARBA:ARBA00017139};
DE AltName: Full=Protein FAM33A {ECO:0000256|ARBA:ARBA00029651};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000011387.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000011387.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000011387.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}.
CC -!- SIMILARITY: Belongs to the SKA2 family.
CC {ECO:0000256|ARBA:ARBA00010684}.
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DR RefSeq; XP_008331710.1; XM_008333488.2.
DR AlphaFoldDB; A0A3P8VAE7; -.
DR Ensembl; ENSCSET00000011527.1; ENSCSEP00000011387.1; ENSCSEG00000007324.1.
DR GeneID; 103395703; -.
DR KEGG; csem:103395703; -.
DR CTD; 348235; -.
DR GeneTree; ENSGT00390000009588; -.
DR OMA; CQTVKEM; -.
DR OrthoDB; 1382337at2759; -.
DR Proteomes; UP000265120; Chromosome 19.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000940; C:outer kinetochore; IEA:InterPro.
DR GO; GO:0005876; C:spindle microtubule; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR Gene3D; 6.10.250.1380; -; 1.
DR InterPro; IPR026762; Ska2.
DR InterPro; IPR042091; Ska2_N.
DR PANTHER; PTHR32017; SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR32017:SF3; SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF16740; SKA2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 2..116
FT /note="Ska2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16740"
SQ SEQUENCE 229 AA; 25336 MW; 852501A896D4C055 CRC64;
MEATVDKLEA MFQKSQADLE YMEKRLRLDF INTTAENGCA AEENPAVVME RLRALKAKHA
ALCSQVKEIA AVQKESMDSI RSNMEGAMKL VQRFQQTADV EVEPLTEPER AAAELFLASA
PCQTTAQAPP AVAAPEHQQS PSSDYDEVSE AMLKTVPSIM RSNIQLADLN VFYRQLQQHF
STNSGALSVQ KMKSLKMKVS DSKLRLLQHL SLVEQDRKGQ VRLVKGGGA
//
