ID A0A3P8VAI7_CYNSE Unreviewed; 854 AA.
AC A0A3P8VAI7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Semaphorin 3C {ECO:0000313|Ensembl:ENSCSEP00000011427.1};
GN Name=SEMA3C {ECO:0000313|Ensembl:ENSCSEP00000011427.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000011427.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000011427.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000011427.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; A0A3P8VAI7; -.
DR Ensembl; ENSCSET00000011567.1; ENSCSEP00000011427.1; ENSCSEG00000007345.1.
DR GeneTree; ENSGT00940000159379; -.
DR Proteomes; UP000265120; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd05871; Ig_Sema3; 1.
DR CDD; cd11251; Sema_3C; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF25; SEMAPHORIN-3C; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 129..612
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 691..756
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 808..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..854
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 854 AA; 96401 MW; 16E4650681DC2E53 CRC64;
MELQVKMQEN NLTLGPKVKS NQFVMLVWIR GFLVPGTSVH NTGGDGTLCV FIHSSFGLGI
SGQFYWDYCC WTCLQRESSD QSSILSGAVM GRPEGLARPP LVSTMELSLL ALCLFVSTGV
SSLPQPVPRV SLSFDDLQAS HSFEHYSISD KAMDYRILHM DEDQDRMYVG SKDHVLSMDI
NNITHGTLKV FWPASPSKIE ECQMAGKDPT HGCGNFIRVV QPYNRTHLFM CGSGAYSPVC
VFINRGRRPE EQVFHIDSRT ESGKGRCSFN PQVNTVSVML NQELFSGMYI DFMGTDAAIF
RSLTKQNAVR TDQHNSKWLS EPNFIDAHLI PDGTDPNDAK LYFFFRERLT DNNGNTKNIH
TMVARVCPND IGGQRSLVNK WTTFLKARMV CSVLEEDGTE THFDELENVF LLETEQPKSL
LVFGVFTSTS SVFKGSAVCV YNMADVLTVF NGPFAHREGP NFQWTAFQGR IPYPRPGTCP
GGAFTPDIQT TKEFPDDVVT FVRNHPVMFN PIYPVGRRPL VVRTNAEYRY TSVAVDQVMA
ADGNYQVLFL GTDKGTIQKV IVLPSNHSLQ EDLILEELEV FKDQAPVTNL RISSKKQQLY
VSSEFGVSQV SLHRCHAYGS ACADCCLARD PYCAWDGLSC SRFYPSNKRR SRRQDVMHGN
PLTQCRGFNL KAYRNAVEMT QYGVKNNTTF LECLPKSPQA SIRWLIHRDN DRRKEVKLSE
RVLSTEQGLL IRSVQLSDQG LYYCLTTENG FKRTVAKIRL RVLSEAMVSV LMDKQQPWAW
ASSLHPKALL SAFSPAESMA VQQYCKERKE LQKQQQPKQQ QPQPPGPLRG DLAKLKPLLD
LRKSRNRRNH LPDV
//
