ID A0A3P8VAP6_CYNSE Unreviewed; 1953 AA.
AC A0A3P8VAP6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Multiple PDZ domain crumbs cell polarity complex component {ECO:0000313|Ensembl:ENSCSEP00000010321.1};
GN Name=MPDZ {ECO:0000313|Ensembl:ENSCSEP00000010321.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000010321.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000010321.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000010321.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSCSET00000010445.1; ENSCSEP00000010321.1; ENSCSEG00000006527.1.
DR GeneTree; ENSGT00940000155586; -.
DR Proteomes; UP000265120; Chromosome 1.
DR CDD; cd00992; PDZ_signaling; 12.
DR Gene3D; 2.30.42.10; -; 12.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR InterPro; IPR015132; L27_2.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR032078; MPDZ_u10.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR PANTHER; PTHR19964:SF44; PATJ HOMOLOG; 1.
DR Pfam; PF09045; L27_2; 1.
DR Pfam; PF16667; MPDZ_u10; 1.
DR Pfam; PF00595; PDZ; 12.
DR SMART; SM00228; PDZ; 12.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 12.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 12.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 3..63
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 121..208
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 239..319
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 350..436
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 521..602
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 669..743
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 955..1023
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1095..1187
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1286..1369
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1517..1600
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1613..1695
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1751..1837
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1870..1953
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 68..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1059..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1953 AA; 209787 MW; D8D59F6CAB73514F CRC64;
MIETMDTQRA LQAVERLQAK LKERGELASE EKLSLLKSVL QSPLFHQILA LQKSVQLLRD
QVNIPVQRGG DPVDHNTAVK SNGSHAPYSD TSPATHIISK SSCEEFEHVV QSMAQGRHMT
NVELQKPVSG GLGFSVVGLK SEDRGELGIF IQEIQPGSVA HCDGKLREAD QILAINGQPL
DQTVTHQQAI SILQSAAERV QLTVARGPIP QLASPVVSRT PSAASTVSAN SNALQHVETI
EIVNDGTGLG FGIVGGKTTG VIVKTILPGG IADQDGRLRS GDHILRIGDT DLCGMGSEQV
AQVLRQCGNR VKLVVTRGPA EETPSAVMPV VLPTVNEQQG YEEEEAEAFD VSLTKNTQGL
GITIAGYIGD KNSDPSGIFV KSITKDSAVD QDGRIHVGDQ IIAVDGVNIQ GYTNQQAVEV
LRHTGQTVHL KLMRRGFRPD EIGPAPVQNV TISPPSSSIN TGNTTANNEM PLHTMSEGSD
VKLTADQLTE DKHVMKLTLF EEEQLIQKWQ EILGASNEVV VAQVEKFTTN SGLGINLEAN
SGHHYIRSIL PEGPIGRCGK LFNGDELLEV NGISLIGESH KEVVRILKEL PVYVIVTCFR
PTSHLQTDVE AVHPQPEAVS TPKLKKHLDL RSLLVPENSE VNTVAVIQDN VTEETTGAPL
AMWELEVQNI ELEKGERGLG FSILDYQDPL DPAKTVIVIR SLVPNGVAEQ DGRLLPGDRL
MYVNTTDLEN ATLEDAVQAL KGAKLGNVQI GVAKPLPIDT SEADLSDEKF FDHSYTGQED
HTFQASMIAL HGSSCSPDLD FLHSSTPKLT ARLDLLDEHP FMTPNFTAPT GLEDGTQVFP
TETPASFSPQ SLRGHTLAYD AILSSSNCYL AHLPAKEEPE ECSGSYSPFA EIRNRSYAQE
EPVMSHFQKE PASSMVDIRD RTFLTELKDE EAGVEEWAED SDKEALTSGS SYDRTITVVK
GNSSLGMTVS AMKDGLGMQI RSIIHGGSIS RDGRLGVGDL ILAVNGEPTT NLSNVQARAM
LRRHSLIGPD LDIKYVPAEY LEEYKASQEQ SKPDVFSGAT LASAPVPKEI PNLPEREDGE
GEESDSYSNW NQPRTVELFR APGKSLGISI VGGRGMGSRL NNGEVMRGIF IKHILVDSPA
GQNGTLKTGD RIVEVDGVDL RDATHEEAVE AIRKAGNPVT FLVQSMIHRP RQPLITDAGE
ERAATLTRDK DKPAKREAAK ASPTSSVLPL PVVPHVGETD TDVLTEIPGR PAEAEEEKEG
EEKDEFGYSW NTVIQRYGSL PGVLHMIELE KGKTGLGLSL AGNRDRARMS VFVVGIDPNG
AAGRDRRMVV GDELLEINGQ VLYGHSHQNA SSIIKSSPSK VKIIFVRNTE ALNQMAVGPV
RDQEEDTVEP HSEFETTVAN DDASKTTEHI TKLKEDELPG INFVEQSTNS RDKILSTFKD
VCTKPGDTLS AVNGESLLGC TVEKSTCQDD DVSDTVLPSS LSLPEAETIT SLSRSSTPST
LTCDPATCPI IPGCETTIDI SKGRTGLGLS IVGGCDTLLG AIIIHEVYEE GAASKDGRLW
AGDQILEVNA IDLRAASHDE AINVLRQTPQ RVRLTVYRDE AQYKEEDLWD SFTVELHKKP
GQGLGLSIVG RRNDTGVFVS DIVRGGLVDV DGRLTQGDQI LSVNGEDVRS ATQEAVAALL
KCCVGPIKME VGRFKAGPFH SERRLSQSSQ ISDACSSKAA LLLCSDAGNL LSNPDNLSHS
QESLDCPETR TVEFTKGPSD SLGISIAGGV GSPLGNIPIF IAMMNPVGLA AQTQKLKIGD
RIVSICGNST EGMTHSQAVT LLKNATGTVQ LQVVAGGDST VTGPCQDQAG GALTPGCIFQ
DDIGPPQYKS ITLERGPDGL GFSIVGGHGS PHGDLPIYVK TVFGKGAAAE DGRLKRGDQI
MAVNGQTLES VTHEEAVGIL KRTKGSVTLT VLS
//
