ID A0A3P8VB67_CYNSE Unreviewed; 1689 AA.
AC A0A3P8VB67;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Roundabout homolog 1 {ECO:0000313|Ensembl:ENSCSEP00000011642.1};
GN Name=ROBO1 {ECO:0000313|Ensembl:ENSCSEP00000011642.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000011642.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000011642.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000011642.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_008307322.1; XM_008309100.2.
DR STRING; 244447.ENSCSEP00000011642; -.
DR Ensembl; ENSCSET00000011782.1; ENSCSEP00000011642.1; ENSCSEG00000007416.1.
DR GeneTree; ENSGT00940000154477; -.
DR InParanoid; A0A3P8VB67; -.
DR Proteomes; UP000265120; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008046; F:axon guidance receptor activity; IEA:InterPro.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro.
DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd07693; IgC_1_Robo; 1.
DR CDD; cd05725; IgI_3_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR032986; Robo1_Ig-like3.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF9; ROUNDABOUT GUIDANCE RECEPTOR 1; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1689
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018102523"
FT DOMAIN 70..166
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 172..259
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 264..348
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 353..448
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 457..537
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 565..659
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 678..775
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 780..876
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 35..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1467..1689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1358
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1485..1500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1527..1543
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1560..1575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1582..1614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1634..1653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1689 AA; 183718 MW; D0588BE7450C6E5F CRC64;
MRGKQMRVAA LCAVVLLTQA LTQELPSIPE IGVAREGVSD GTTPPPANEH EDDNSLGYTG
SRLRQEDTPP RIVEHPSDLI VSKGEPATLN CKAEGRPTPT VEWYKDGERV ETDRDNPRSQ
RMLLPSGSLF FLRIVHGRRS KPDEGSYVCV ARNYLGEAVS HNASLEVALL RDDFRQNPAD
VIVAAGDPAV LECQPPRGHP EPTISWKKDG VNIDDRDERI TIRGGKLMIT NARKSDAGKY
VCVGTNMVGE RESEIAELTV LERPSFVRRP GSQVLLVDQS VEFRCEARGD PVPTVRWRKD
DGELPKGRYE IREDHTLKIR RLISADVGSY TCVAENLVGK AEASAMLTVH VPPAFVVRPR
NQVVGVGRTV TFQCEATGNP QPAIFWQQEG SQNLLFSSQP PQPSSRFSVS QTGDLTITDA
ERSDMGYYSC QALNIAGSVI TKALLEVTDV VSDRPPPVIR QGPTNQTVAV DGTVVLSCMA
LSNPTPTILW RKDGLLVSTH DSRIKQLDTG ALQIRYAKLG DTGTYTCIAS TPSGEASWKA
HLEVQEFGVP VQPNRPTDPN LIPSSPSKPE VTDVTRTSVT LSWKPNLNTG ATPTSYIIEA
FSHASGSSWQ TLAEHVKTES FVLKGLKPSA VYLFLVRAAN AYGLSDPSPI SDAVKTQDIP
PTSQGVDHRQ IQRELGDVVI HLHNPTILSS SSVRVQWTVE QQSQYIQGYK VMYRPSPEGL
QRSDWAVFEV RTPGEDSAVV PQLRKGVTYE FKVHPFFNEF QGTDSDVKIG KTLEEAPSAP
PREVTVTESG DNGTAIVVSW QPPPPEDQNG VVQEYKIWCL GNESRYHINR TVDGSTFSVL
IPSLTPGIRY SVEVAASTGA GPGVKSDVTY FQLDASGRMT ETGADENPLT QQISDVVKQP
AFIAGIGAAC WIILMVFSIW LYRHRKKRNG LSSSYAGIRK VPSFTFTPTV AYQRGGEGVS
SAGRPGLLNM GDSATQPWLA DTWPNSCSNH NDCSINCCTA GNGNSDSNLA TYSRPADCIA
NYNNQMENKQ TNLMMPESGL YGDVDLSNKI NEMKTFNSPN LKDGRFMGPG GQPTPYATTQ
LIQSSIMGNN INPDRGTGGS GGGPVGGGEV NEKHCWKPPP IQHQKQEMGS QLQYIIMEQN
KLNKDRCRGG ESPMPTIPYN QAHDSHTGGS YNSSDRGSSS TSGSQGQKKG MRTPKLPKQS
TMNWADLLPP PPANPPPSRS VEEYALSMQE SCDPDTQCPM PPSHMYLQPD ELEEEEELER
GPTPPIRGAA SSPAAVSYSH QSTATLTPSP QEEMQPMLQD PPDSHERRRH AVSPSPPPRP
LSPSHTYGYI TSPLALDTDG MEEEEDIMEE EEDEGDDTDA EVAKMHYHHT HPHIHPHHSQ
MHPRRLLLRG LEQTPASSMG DLESSVTGSM INGWGSASEE DNVSSGRSSA VSSSDGSFFT
DTDFAQAVAA AAEYSGLRVA KYPNIHSQEV GGPSARKYQI NPTGHRPGSP VSTDSNMSMA
AVNRRPPKKQ KQHNAGHPGN QRRDPYNEDL PPPPIPPPAV LKSPTHPSKA TLEGRGVISP
KAGEGRDKRG GSGGYRPRDG SDPRTGSSER KEAQERQKSA HGEKGNRHEG STASKARQHP
GSEDIPPYSR PQFPTVNSPR DPSSSSSMSS RGSGGRRRGE GGRRNPTDMS LVTTGALQAG
DEELEMPES
//
