GenomeNet

Database: UniProt
Entry: A0A3P8VCJ3_CYNSE
LinkDB: A0A3P8VCJ3_CYNSE
Original site: A0A3P8VCJ3_CYNSE 
ID   A0A3P8VCJ3_CYNSE        Unreviewed;      1258 AA.
AC   A0A3P8VCJ3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Apoptotic protease-activating factor 1 {ECO:0000256|PIRNR:PIRNR037646};
DE            Short=APAF-1 {ECO:0000256|PIRNR:PIRNR037646};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000010170.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000010170.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000010170.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent
CC       autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the
CC       activation of caspase-3 and apoptosis. This activation requires ATP.
CC       {ECO:0000256|PIRNR:PIRNR037646}.
CC   -!- SUBUNIT: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
CC       {ECO:0000256|PIRNR:PIRNR037646}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037646}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_008313764.1; XM_008315542.2.
DR   STRING; 244447.ENSCSEP00000010128; -.
DR   Ensembl; ENSCSET00000010250.1; ENSCSEP00000010128.1; ENSCSEG00000006505.1.
DR   Ensembl; ENSCSET00000010266.1; ENSCSEP00000010144.1; ENSCSEG00000006505.1.
DR   Ensembl; ENSCSET00000010292.1; ENSCSEP00000010170.1; ENSCSEG00000006505.1.
DR   GeneID; 103382677; -.
DR   KEGG; csem:103382677; -.
DR   CTD; 317; -.
DR   GeneTree; ENSGT00940000157710; -.
DR   OMA; YHMANAN; -.
DR   OrthoDB; 2995530at2759; -.
DR   Proteomes; UP000265120; Chromosome 8.
DR   GO; GO:0043293; C:apoptosome; IEA:InterPro.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0097190; P:apoptotic signaling pathway; IEA:InterPro.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd00200; WD40; 2.
DR   Gene3D; 1.25.40.370; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR017251; Apaf-1.
DR   InterPro; IPR041452; APAF1_C.
DR   InterPro; IPR048975; APAF1_WHD.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011044; Quino_amine_DH_bsu.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR   PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR   Pfam; PF21296; APAF-1-like_WHD; 1.
DR   Pfam; PF17908; APAF1_C; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF00400; WD40; 9.
DR   PIRSF; PIRSF037646; Apop_pept_activating-1; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 12.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF117289; Nucleoporin domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 6.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|PIRNR:PIRNR037646};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR037646};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR037646};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037646};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   DOMAIN          3..92
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   REPEAT          657..698
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          746..787
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          880..921
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          1004..1035
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          1045..1089
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          1090..1121
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          1132..1173
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   1258 AA;  142865 MW;  712A92C8744167EB CRC64;
     MALDEASRSC LLRFRHRLEQ DIKPSYLMDH MISDGVISVD EEEKVRIQPT RKDQAASLIE
     LLLRKDNCAF ISFYNALVKE AYDDLARLLY DNLPQISSNG YEKLSDENTS YVQMLLSEGG
     VPQRPVVFVS RPELLNRLRE KLYRLKEDSG WVTVFGMAGS GKSVLAAEAV RHQDLLGDCF
     PGGVHWLSIG QLEKPDLLLK IQSLCFRLEQ NLHSHSAHRC PNSLDEAKER LRFLMLRRYP
     RSLLMLDDVW DSSVLKVFDI HCRILLTTRN RGLTDSVSGA KYEVEVESGL EESKALEILG
     LYTDIQPHGL PEEARRIVVE CKGSPLVVSL IGALLKDKPN RWQYYLRQLQ QKQFKRIRKS
     SSYDYDALDQ AMAASIEVLP EEHQELYKYL TVFEKDIKIP AKVLSVLWDL EEEEVEDILQ
     GFVDKSLLFV DNNNKPCLYY LHDLQLDFLV EQNRNQLESL HTKMVRQYQQ HYRDGPPISK
     DKDCLYWIRF LTYHMAKASL SQELYSLMFS LDWVCTKAQI MGPAHLINDY MEYGPSLDKE
     NDGVRSHFQE FLSLNGHQLE QRPFPDVVQL ALSEPHTSDV YRQALVQALD RANRGKLYFD
     WLNKNSVENL SLLVIHPHQG SINSACFSND GTKIATCGAS KTLKVFRSTT GEKLTEIQAH
     DDEVLCCAFS PDDCLIATCS SDRKVKIWNL DRDMLLRVFS EEHEEQINHC QFTNLRRQVL
     LATCSNDKFL NVKLWNLNKP TCQNTLFSHL EPVNHCCFSP NDTYLSTSSN DGTVKLFQVS
     SANVWKTINV SSMFSESDET VPVKCSTWTG DGKRIACAAR NAVLLFDVET SDMLLEIKTN
     RLSTVQYCHA CPTSNLLAIA FSNYGVELWD LVANKKMADC SGHLSWVQRV QFSLDGSQLL
     SCSDDQTVRL WETKKVHTTS AVCLKRDSDV VFNDGEVVVS AADNCNRLQV REGPSGSLLF
     QSEEKSSRIR CTCLCRQPFV VALGQENGTV QVLELASGKP LATLQGHTKT VLHCKFIHDG
     QTLITSSEDT TIRVWAWPSG ECKVLRGHKE QVRCFSLLSN SASESRLLSW SYDGTVKVWD
     IKSGETMRDI DAHVGAILSC HVSPDGCFFA TASADKTVKL WLCETWQCVH RLSGHQECVR
     SCRFSWDSRR LATGDDNGEI RLWNVKDGTL LKICSRDGKD GMDSLHGGWV TDLHFSPDDS
     LLVSTGGYIK WWDVERGEAL QTFFPRGNAL KRIHVSSDFS TFVTVDSIGF LYVLQRVV
//
DBGET integrated database retrieval system