ID A0A3P8VCJ3_CYNSE Unreviewed; 1258 AA.
AC A0A3P8VCJ3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Apoptotic protease-activating factor 1 {ECO:0000256|PIRNR:PIRNR037646};
DE Short=APAF-1 {ECO:0000256|PIRNR:PIRNR037646};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000010170.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000010170.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000010170.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent
CC autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the
CC activation of caspase-3 and apoptosis. This activation requires ATP.
CC {ECO:0000256|PIRNR:PIRNR037646}.
CC -!- SUBUNIT: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
CC {ECO:0000256|PIRNR:PIRNR037646}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037646}.
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DR RefSeq; XP_008313764.1; XM_008315542.2.
DR STRING; 244447.ENSCSEP00000010128; -.
DR Ensembl; ENSCSET00000010250.1; ENSCSEP00000010128.1; ENSCSEG00000006505.1.
DR Ensembl; ENSCSET00000010266.1; ENSCSEP00000010144.1; ENSCSEG00000006505.1.
DR Ensembl; ENSCSET00000010292.1; ENSCSEP00000010170.1; ENSCSEG00000006505.1.
DR GeneID; 103382677; -.
DR KEGG; csem:103382677; -.
DR CTD; 317; -.
DR GeneTree; ENSGT00940000157710; -.
DR OMA; YHMANAN; -.
DR OrthoDB; 2995530at2759; -.
DR Proteomes; UP000265120; Chromosome 8.
DR GO; GO:0043293; C:apoptosome; IEA:InterPro.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0097190; P:apoptotic signaling pathway; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00200; WD40; 2.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR017251; Apaf-1.
DR InterPro; IPR041452; APAF1_C.
DR InterPro; IPR048975; APAF1_WHD.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR Pfam; PF21296; APAF-1-like_WHD; 1.
DR Pfam; PF17908; APAF1_C; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF00400; WD40; 9.
DR PIRSF; PIRSF037646; Apop_pept_activating-1; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF117289; Nucleoporin domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 6.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|PIRNR:PIRNR037646};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR037646};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR037646};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037646};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3..92
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REPEAT 657..698
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 746..787
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 880..921
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1004..1035
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1045..1089
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1090..1121
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1132..1173
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 1258 AA; 142865 MW; 712A92C8744167EB CRC64;
MALDEASRSC LLRFRHRLEQ DIKPSYLMDH MISDGVISVD EEEKVRIQPT RKDQAASLIE
LLLRKDNCAF ISFYNALVKE AYDDLARLLY DNLPQISSNG YEKLSDENTS YVQMLLSEGG
VPQRPVVFVS RPELLNRLRE KLYRLKEDSG WVTVFGMAGS GKSVLAAEAV RHQDLLGDCF
PGGVHWLSIG QLEKPDLLLK IQSLCFRLEQ NLHSHSAHRC PNSLDEAKER LRFLMLRRYP
RSLLMLDDVW DSSVLKVFDI HCRILLTTRN RGLTDSVSGA KYEVEVESGL EESKALEILG
LYTDIQPHGL PEEARRIVVE CKGSPLVVSL IGALLKDKPN RWQYYLRQLQ QKQFKRIRKS
SSYDYDALDQ AMAASIEVLP EEHQELYKYL TVFEKDIKIP AKVLSVLWDL EEEEVEDILQ
GFVDKSLLFV DNNNKPCLYY LHDLQLDFLV EQNRNQLESL HTKMVRQYQQ HYRDGPPISK
DKDCLYWIRF LTYHMAKASL SQELYSLMFS LDWVCTKAQI MGPAHLINDY MEYGPSLDKE
NDGVRSHFQE FLSLNGHQLE QRPFPDVVQL ALSEPHTSDV YRQALVQALD RANRGKLYFD
WLNKNSVENL SLLVIHPHQG SINSACFSND GTKIATCGAS KTLKVFRSTT GEKLTEIQAH
DDEVLCCAFS PDDCLIATCS SDRKVKIWNL DRDMLLRVFS EEHEEQINHC QFTNLRRQVL
LATCSNDKFL NVKLWNLNKP TCQNTLFSHL EPVNHCCFSP NDTYLSTSSN DGTVKLFQVS
SANVWKTINV SSMFSESDET VPVKCSTWTG DGKRIACAAR NAVLLFDVET SDMLLEIKTN
RLSTVQYCHA CPTSNLLAIA FSNYGVELWD LVANKKMADC SGHLSWVQRV QFSLDGSQLL
SCSDDQTVRL WETKKVHTTS AVCLKRDSDV VFNDGEVVVS AADNCNRLQV REGPSGSLLF
QSEEKSSRIR CTCLCRQPFV VALGQENGTV QVLELASGKP LATLQGHTKT VLHCKFIHDG
QTLITSSEDT TIRVWAWPSG ECKVLRGHKE QVRCFSLLSN SASESRLLSW SYDGTVKVWD
IKSGETMRDI DAHVGAILSC HVSPDGCFFA TASADKTVKL WLCETWQCVH RLSGHQECVR
SCRFSWDSRR LATGDDNGEI RLWNVKDGTL LKICSRDGKD GMDSLHGGWV TDLHFSPDDS
LLVSTGGYIK WWDVERGEAL QTFFPRGNAL KRIHVSSDFS TFVTVDSIGF LYVLQRVV
//