ID A0A3P8VE06_CYNSE Unreviewed; 1299 AA.
AC A0A3P8VE06;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Adhesion G protein-coupled receptor A3 {ECO:0000313|Ensembl:ENSCSEP00000010700.1};
GN Name=ADGRA3 {ECO:0000313|Ensembl:ENSCSEP00000010700.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000010700.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000010700.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000010700.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR Ensembl; ENSCSET00000010829.1; ENSCSEP00000010700.1; ENSCSEG00000006830.1.
DR GeneTree; ENSGT00940000157235; -.
DR Proteomes; UP000265120; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF2; ADHESION G PROTEIN-COUPLED RECEPTOR A3; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1299
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018303837"
FT TRANSMEM 731..752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 764..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 797..820
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 886..909
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 954..975
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 987..1010
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 228..326
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 309..404
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 729..1012
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1057..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1167
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1299 AA; 144194 MW; 4968F6DC3766727A CRC64;
MRVDLLLLFV ILLLGGSRGG AGGSALSSDC KPYDERPKGA VKSLSTDRKV VCSNMELHQV
LPPESFPNRT VTLIYNNNNI QELKNGSFSG LSTLEKLDLR SNLISHIEPG AFLGLPALKR
LDLSNNSIGC LNIDIFKGLS SLVRLNLSGN IFSSLTPGIF DSLVSLKSEF QTPYLLCDCN
LAWLLRWIKE RNIAVKNTKC SFPQSLQGQL ITLFKPEILT CDAPLELPSF QLTPSQRQVV
FQGDSLPFQC QASFVAEDMQ VLWFQNGRMV KPDAAQGIFI EKRMVQNCSL IASALTISNI
QPGFTGNWEC RIWTSRGNTT RTVHIVVLES SAKYCAPERI SNNKGEFRWP RTLAGIKAYL
PCNRLPTSAG TYSGSSVEEQ RAWRYCDREG LWAEEDYSHC EFQKDVTRFL YLINQMPLNE
SNVVHRAQRL LVYTIDAANF SDKMDIIIVA EMIEKFGKFV EKFKDLGEVM VSMASNLMLA
DERVLWMAQR EAMACSRIVA CLQKIAVYRL ASAQAFSLTS PNIALEAHSV RANEWNGMSC
MLFQRLSPER TPNQDRQLTF KCNTTSSISS ILYKSTVVEA SLQLPQSLFT QATPAGQAED
PVYKLHLLAF RNGKFFPSTI NSSQLADGLK RKSVATPVIM AKIDGISLHV LRTPINITLR
RFARGSDPVS ASWNFSLGGG QGGWQSEGCR ILTHHDNVTT ISCSSLGNYG LLMDLSNVEY
FTPGIQPLHP VIYATSIILL LCLLTIIISY IVHHRSVRVS RKFWHMLVNL CFHVSLTCGV
FVGGINQTHY ASVCQAVGIL LHYSTLATAL WVGVTARNIY KQLTRKTKRY EELDEPPPPP
RPMLRFYLIG GGIPIIVCGI TAAANIKNYG SRTSAPYCWM AWEPSIGAFY GPVGFIIFVN
CMYFLSILLQ LRRHPERRYE LKEMTEEQQH LAASSVMSAP HTVPLSSLEN EHTFSAQLMG
AAGALGLYAA LWVFGAMAVS QDHPYDLAFT CLFGVAALAL GAFMVAHHCV NRQDMRRYWS
QTCCSGRRAY FAQEDVLLSQ PDVALASTAG FVNKADGEST KCGHSSADSS YTNKSGPSMR
NSTHGSKLTN LHAEAAQCKP ASAPVSANGA AILDNSLTEH SVDNEIKMHV APLEVQFRPM
NNVNAHSTAP NGHIGRHHKN RARSHRASRL TVLREYAYDV PTSVEGSVQS SSNRRHHYYD
VAARNSRRAA YMAYRERHQS QLQQDSSDSA SLPRRSRYSD KGSTSRPSST ELENLPKSYG
LNLITPNGTL KENSQTVPLI NTETTAIIKT GLWKHETTV
//
