ID A0A3P8VF86_CYNSE Unreviewed; 1279 AA.
AC A0A3P8VF86;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSCSEP00000011891.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSCSEP00000011891.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000011891.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000011891.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000011891.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR AlphaFoldDB; A0A3P8VF86; -.
DR STRING; 244447.ENSCSEP00000011891; -.
DR Ensembl; ENSCSET00000012032.1; ENSCSEP00000011891.1; ENSCSEG00000007658.1.
DR GeneTree; ENSGT00940000154127; -.
DR InParanoid; A0A3P8VF86; -.
DR OMA; IFFAQIK; -.
DR Proteomes; UP000265120; Chromosome 11.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1279
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018120489"
FT TRANSMEM 294..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 629..656
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 806..833
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1023..1089
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1279 AA; 144010 MW; 1868E1223863AE0B CRC64;
MPQVHMTAAK LSILSFILNI QLTCLSPPAA HQRCGQASVI QVRGRDAGHK SDSESTSPET
TWCLSFPSSQ STSPETTWCL SFSSSSAAST LKQKLGVKFS SSGVPPSSSS GPQSRSLYAS
FNHISNILHS RVQRSTLTRH NTGPTLPQVQ NAPPSSAYRV TFNKCVQVKR HTDPPQLTFF
LRIHNMGPVG GTNLSHVAIR DSLSGIIPLR TEGRVVERGY QTFAIDSLSA GSQVVVNYTA
HIRSPKNEVL DLPAFLTFSN ASQNDVSMFG PLTANLTLRV NSTDRIHPNH GVHFAGFVAG
FFMIMVLLLL GFLAVNQIGL RTRLHLLQQR KRGDPDPEDA DCNTSGTIKD EATFEDKLVD
IMVLEDPQNM NQALENLEMS TLLRATNNLE ANRIQIYKDV VSSLLGSLRS QGQATAQAQQ
RLLSVLHGQL QGMEGRLKEE RGSRMAALAG QCNLETREEM EAEHCREAAE KAQAELLCRH
ADQQDLLQCS ALLEKLHKVS QSQLQRILLV RHEEASARVQ RQIIEWRRVE LHKIFAEELE
EATRMGELEK NTVKSLQHEY FTCQDQLEEV LDVVLANQRY VLAERHAQRK FLVHSLHSLN
SLISDTFSCA SSNLDSWFAH LRRGSTVPVE QADHLQEKAQ KELLVLRQRL DEALNQERRA
MRCGLIKKRR ELISEMLRVH KQREKDLSGL SRGVDRRMDV AQNLHCWQKI LTTHNLELAE
LINNLDEEAA ADIRKMTMRA IQGAVAEVKA ILPSTAQTLL SSLPPGTNHS LLQVEPEQGA
GQAQGQGAGT LLQGQERLHQ EGKAALRTLS STREALQAAM ERELQEQKEI RAHCRAFFRC
LCSTQLTLSE DDRLKIKLEF QKCLSVMDRC LVLPHAISRT KLHTSLAAWK KDCEKQMINT
QSKGKTGKAR QHTQTHDLLF FQKRLEDRIQ LFENSKQRES SVRNKVLEEM QREREDELRS
QADSLAIQMA AIHHQKAERR TKVLETSRAM LSLHSLLIQL LRMRKSLEKQ DMALSIQNHC
LGLEEAEQQL LKDRTELSSL LQQDCRMTSI LQEALYKSDQ VTAILTESLE ERTANNQAIE
DLKEQMELKR LYANCDQDLE FASQLVKQGQ LSAEVLLEIL RLLLPTLPES ELLSITDALY
PKQHPVTSSK EPEPHLETAI PLTTASLSSR SHRLQEKRQS LMEKLLPRLR LLFPNDAEEA
EKEKEDFTKG QQPIYKSALG ENAVGQPHSA LGRSSTGERL FVFRDAPGST NDYVDVPRKK
TKRSFLNRKK TSVAPTNIS
//