ID A0A3P8VFH2_CYNSE Unreviewed; 1891 AA.
AC A0A3P8VFH2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000011991.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000011991.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000011991.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC Nav1.4/SCN4A subfamily. {ECO:0000256|ARBA:ARBA00038083}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 244447.ENSCSEP00000011991; -.
DR Ensembl; ENSCSET00000012133.1; ENSCSEP00000011991.1; ENSCSEG00000007695.1.
DR GeneTree; ENSGT00940000167352; -.
DR InParanoid; A0A3P8VFH2; -.
DR OMA; RWPILMN; -.
DR Proteomes; UP000265120; Chromosome 8.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 121..144
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 189..208
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 220..241
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 403..430
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 595..619
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 631..652
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 672..693
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 714..742
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 804..827
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1063..1081
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1102..1118
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1130..1150
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1179..1205
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1300..1323
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1382..1400
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1412..1434
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1446..1465
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1499..1527
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1603..1626
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1643..1678
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1834..1857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 427..461
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..961
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..976
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1019
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1891 AA; 214745 MW; D0679C6CD05A69EB CRC64;
MVTALPTSST DAFRPFTRES LAQIKRAQEE RKKAAEVEGH EEEQEEAPNA DLEAGKSLPM
IYGDPPPEKL GVPLEDLDPF YRAQNTFIVI SKGNTIYRFN AEPACYILSP FSSVRKVAIN
ILIHSLFSMF IMITILSNCV FMTMSNPPAW SKTVEYVFTG IYTFEATVKV LSRGFCVGSF
TFLRDPWNWL DFMVISMAYI TEFVDLGNVS ALRTFRVLRA LKTITVIPGL KTIVGALIQS
VKKMVDVMIL TVFALAVFAL IGLQLFMGNL RHKCVRWPID TNSTFEFFNT TSALNDTMPI
ETSMGIGSTA YSNSTFNFEE YIENPENHYF LEGSLDALLC GNSSDAGKCP VGFTCMKAGR
NPNYGYTSFD SFGWAFLALF RLMTQDYWEN LFQLILRAAG KTYMLFFVVI IFLGSFYLIN
LILAVVAMAY DEQNQATIRE AKEKEEEFQR LLEQLRNQEQ AHIQGSRASL CSKKSLTHQS
LSDLEDAVQS LEPDGTIKDC NGRVIPRLIV RAPTLVRSAV DYEDKEKPLG SVNNMLQPYE
PGGAQRRGSA VSERSSAAME ELEDAQRPCP PVWYKFANIF LKWNCCKQWV VFKKWVYFVV
MDPFVDLAIT ICIVLNTLFM SMEHYPMTPE FDHMLLVGNL VFTSIFTAEM VFKLIAMDPY
YYFQVGWNIF DSIIVTLSLV ELGLANVQGL SVLRSFRLLR VFKLAKSWPT LNMLIKIIGN
SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKDCVCKIAE DCELPRWHMN DFFHSFLIVF
RILCGEWIET MWDCMEVAGA GMCLVVFLMV MVIGNLVVLN LFLALLLSSF SGDNLSAGDD
DGEMNNLQIA IGRITRGIDW SKEFAVQMLH RILGTKPKDP EGEPEDDGDP KMEEIEMNHL
DMGQDFKAPD RIANCLVEGR GSGFIVDGEL NLSVPIAQVE SDFENLEEDD EDDEEDANDF
PDEENSHQSI ENSDDEGCLL RKDKMGALTD GDSSVCSTVD YQPPEPEPEE EVEEEPEPVE
PEACFTDECI RRWPCLTVDI TQGRGKKWWN LRRTCFTIVE HDWFETFIIF MILLSSGALA
FEDVYIEKRR TIKIILEYSD KVFTYVFVIE MLLKWVAYGF KTYFTNAWCW LDFFIVDISL
ISLVANWMGY SELGPIKSLR TLRALRPLRA LSRFEGMRVV VNALVGAIPS IFNVLLVCLI
FWLIFSIMGV NLFAGKFYYC VNTTSGEYFH MDVVNNRSEC MVTEDARWVN VKVNYDNVGK
GYLSLLQVAT FKGWMDIMYA AVDSREVEEQ PSYEINLYMY MYFVIFIIFG SFFTLNLFIG
VIIDNFNQQK KKLGDKDIFM TEEQKKYYEA MKKLGSKKPQ KPIPRPTNLI QGVVFDFISQ
RFFDIFIMVL ICLNMVTMMV ETDNQSPEKE DFLFKVNVAF IIVFTGECVL KLFALRQYFF
TNGWNIFDFV VVILSIAGTM LSDLIEKYFV SPTLFRVIRL ARIGRILRLI KGAKGIRTLL
FALMMSLPAL FNIGLLLFLI MFIFSIFGMS NFAYVKKEAG IDDIFNFETF GSSIICLFQI
TTSAGWDGLL LPMLNSNPPD CDPEFENPGT DVKGNCGSPG MGMMFFCSYI IISFLVVVNM
YIAIILENFN VAQEESGDAL CEEDFEMFNE TWEKFDIDGT MFIEYNKLSD FCDALQEPLK
VAKPNRLRLI EMDLPLVIGD RIHCLDVLLA VTQMVLGDTV EMAAMRESIK AKFILSNPTS
DSFAPITSTV RHKEEERAAV VIQRAYRHHL LKRCIHHAAF MYHSKRMGKK DEDEEPPEKE
GLLARKMGVL YGSNVDLAEQ MEQAALDALV NQEPPKPETL LHNSGVPSGP TESPEPNTVI
VPVEVTNEIL LHSAPNPHIL AQQANLRETV V
//
