ID A0A3P8VFY2_CYNSE Unreviewed; 1133 AA.
AC A0A3P8VFY2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=PTPRF interacting protein alpha 1 {ECO:0000313|Ensembl:ENSCSEP00000012156.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000012156.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000012156.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000012156.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC {ECO:0000256|ARBA:ARBA00007026}.
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DR AlphaFoldDB; A0A3P8VFY2; -.
DR Ensembl; ENSCSET00000012299.1; ENSCSEP00000012156.1; ENSCSEG00000007640.1.
DR GeneTree; ENSGT01050000244900; -.
DR Proteomes; UP000265120; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF15; LIPRIN-ALPHA-1; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 819..885
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 911..968
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 992..1061
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 223..385
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 579..613
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 167..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 127539 MW; 443CE4CDA8E57BDC CRC64;
MMCEVMPTIS EAEGPGGGVS SGRRGSGSPL QSDSEGHFES LMVSMLEERD RLLETLRETQ
ENLGLTQGKL HEVSHERDSL KSVFRGSHWF CLRMTVVKRQ AQSPAGVSSE VEVLKALKSL
FEHHKALDEK VRESLVVALE RGSELEEQLT MSRKELAYLR EQSIQKRGLA DGTSEVNHNS
ENTPSTNGKR SSDGSLSQED ESLSGFGKVG ELQEVVDRQS ADLGQMKERM AAMVSRINEL
EEDLDTARKD LIKSEDINTR LQRDLRESLA QKDDMEERIT TLEKGFLISP NEFFPFMFFF
FFLQTEDRNR QLQEKLELAE QKLQQTIRKA ETLPEVEAEL AQRVVALTKA EERHGNVEER
LKQMEAQLEE KNQELLRARQ REKMNEEHNK RLSETVDKLL SESNERLQLH LKERMSALED
KNSLIRELDH TKKLVEDSHH EKEQLLIQIE TLRADNDQGR SRSNSLLHGR SQLGSTPDFR
YPVSASSLLD SNSDHYGSAL VLRRPQKGRV AALRDEPSKV QTLNEQEWER MQQANVLANV
AQAFESDMDA SDLEEDRETI FSSVDLLSPA GQADAQTLAL MLQEQLDAIN NEIRMIQEEK
ESAAIRAEEI ECRVGSGDSL GGRFRSMGSL PPSICAGSSL GGSPPGSGQS TPRRIPRSPN
REMDRMGVMT LAAQDDKATI QCETSPPTTP RSMRLNRDAG HAASHEDIRD IRGLAGLQDG
QGSNPSSSNS SQDSLNKAAK KKSIKSSIGR LFGKKEKGRL SIPGKDSPSQ AGTPEAENSP
KDGLGMATLG GQAEKNRKLQ KKHELLEEAR RQGLPFAQWD GPTVVVWLEL WVGMPAWYVA
ACRANVKSGA IMSALSDTEI QREIGISNPL HRLKLRLAIQ EIMSLTSPSA PPTSRTTLAY
GDMNHEWIGN EWLPSLGLPQ YRSYFMESLV DARMLDHLTK KDLRGQLKMV DSFHRNSFQC
GVMSLRRLNY DRKELERRRD DSQLEVKDVL VWSNERLISW IQAIGLKEYS SNLYESGVHG
ALLALDETFD YNTLALLLQI PTQNTQARAT LEREFNSLMA VGTERRVEED DDKNFRRAPS
WRKKFRPKDM RGASLGVSDT LPANFRVTSS SATSPSTQPK RSPMDVYPHY FYR
//
