ID A0A3P8VG29_CYNSE Unreviewed; 901 AA.
AC A0A3P8VG29;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Probable ribonuclease ZC3H12C {ECO:0000313|Ensembl:ENSCSEP00000013224.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000013224.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000013224.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000013224.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the ZC3H12 family.
CC {ECO:0000256|ARBA:ARBA00010922}.
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DR RefSeq; XP_016895502.1; XM_017040013.1.
DR RefSeq; XP_016895503.1; XM_017040014.1.
DR AlphaFoldDB; A0A3P8VG29; -.
DR STRING; 244447.ENSCSEP00000013224; -.
DR Ensembl; ENSCSET00000013383.1; ENSCSEP00000013224.1; ENSCSEG00000008542.1.
DR GeneID; 103391980; -.
DR KEGG; csem:103391980; -.
DR GeneTree; ENSGT00940000155107; -.
DR InParanoid; A0A3P8VG29; -.
DR OMA; YHRCESP; -.
DR OrthoDB; 180910at2759; -.
DR Proteomes; UP000265120; Chromosome 16.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd18729; PIN_Zc3h12-like; 1.
DR Gene3D; 3.40.50.11980; -; 1.
DR InterPro; IPR040546; Rege-1_UBA-like.
DR InterPro; IPR040757; Regnase_1/ZC3H12_C.
DR InterPro; IPR021869; RNase_Zc3h12_NYN.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR PANTHER; PTHR12876:SF36; RIBONUCLEASE ZC3H12C-RELATED; 1.
DR Pfam; PF18561; Regnase_1_C; 1.
DR Pfam; PF11977; RNase_Zc3h12a; 1.
DR Pfam; PF18039; UBA_6; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 405..430
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 405..430
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 68..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 901 AA; 99526 MW; 655F687393D353A5 CRC64;
MGLKDHLEDG TGHILSLELD LDYLHVESAE RQGSLSSGSG SANILQGRGG ACSVSSNSIE
SRGSCFSTNS SCSSSSSSSS CSNLSEESAV SDSDDERLHN GSGSKPHQPH IHPAESFTDL
QQVRLDLTLD QNPRSQKTPE APAPIDPVIE YRTKVDFALK LGYSEELVLM VLRKLGTNAL
INDILGELVK LGAKTEMEQQ GCSSASCCPS ASSLSPPLSS FNSSLDSCQL LCPSQLLDKE
NLRPVVVDGS NVAMSHGNKE VFSCQGIQLA VDWFLDRGHR DITVFVPAWR KEQSRPDAPI
TDQEILRRLE KEKILVFTPS RRVQGRRVVC YDDRFIVKLA YESDGIIVSN DNYRDLANEK
PEWKKFVDER LLMYSFVNDK FMPPDDPLGR HGPSLDNFLR KKPVIHRKQP CPYGKKCTYG
HKCKFYHPER GTQPQRSVAD ELRASAKMSS ASSKGLVEDA LMPKSQGSGV AEVEPSQRTP
KKQSSAILRS SFSDLVEDRF QVARRGSSSS SSSSCGSNHQ GHVAPGGPSA SASYDPWEHP
VESGGGGYRV AGTSGPAKTY KYHRCKSPEL SYNSLSKAYS GLSLEVSHSP DRFFPVDLRA
SSLPSDCSSD GSISSDSFSP DLLADDAPRC HHHHQQHHHP SYSHLLHHHC SGQHTYPSGR
VPPGLGQPAS YSSPMSQVLQ RKFDIGLEEP SSSTTSHGTP RPFRSPSSYS PPHHQDLPPS
GFSRDLHTYL PQMPNTPPQN HNLIRSRWQE SGLQDSRFYE GSPVFSRRNF SAESEQPLPT
INWEPQYHRS PKPYSDPFTF QSRVHSSHPG LLARNSPTPS SFPQVSFTPI TPNKSPTPLV
PHHQEPQTLD RYQDLRERMF VNLCCIFPPD LVRSVMAKNL HVMDAQELAA AILMEKSRLE
S
//
