ID A0A3P8VGT6_CYNSE Unreviewed; 519 AA.
AC A0A3P8VGT6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Beta,beta-carotene 15,15'-dioxygenase-like {ECO:0000313|Ensembl:ENSCSEP00000013552.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000013552.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000013552.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000013552.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC {ECO:0000256|ARBA:ARBA00006787, ECO:0000256|RuleBase:RU003799}.
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DR RefSeq; XP_008305705.1; XM_008307483.2.
DR STRING; 244447.ENSCSEP00000013552; -.
DR Ensembl; ENSCSET00000013711.1; ENSCSEP00000013552.1; ENSCSEG00000008716.1.
DR Ensembl; ENSCSET00000013729.1; ENSCSEP00000013570.1; ENSCSEG00000008716.1.
DR GeneID; 103376919; -.
DR KEGG; csem:103376919; -.
DR CTD; 53630; -.
DR GeneTree; ENSGT00950000182913; -.
DR OMA; GKLMCQA; -.
DR OrthoDB; 294919at2759; -.
DR Proteomes; UP000265120; Chromosome 3.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR InterPro; IPR004294; Carotenoid_Oase.
DR PANTHER; PTHR10543:SF110; BETA-CAROTENE 15,15'-MONOOXYGENASE 1; 1.
DR PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR Pfam; PF03055; RPE65; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR604294-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 172
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 236
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 307
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 513
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ SEQUENCE 519 AA; 59054 MW; C7ADA328CB426015 CRC64;
MATDFSKNAE ERPEPQKAEI KGNIPSWLQG TLLRNGPGIF TVGETSYQHW FDGMAIIHSF
AFKDGEMTHR SRFLRSDTYK ENMAANRIVV SEMGTMAYPD PSKNFIFKAI TFLHHTVPDF
TDNGASNIIK YGNDYYATSE TNYICKIDPV TLETQDKVDY MKYLPVNLAT SHPHYDREGN
AYNIGTSIAE KGKTKYTLFK VPAASANDED GKPTLKNVEV VCTIPCRSLL MPSYYHSFGM
TDNYIIFVEQ PFKLDILRMA TAYMRGVSWA SCLKFCPEEK TIIHLIDKKT RKEVETKYLT
GTMVVYHHVN AYEEDGHVVF DIIAYDNTSL YEMFYISRLK EHGNTYDENY CKPTYRRFVL
PTSSDKGAAV GENLVKLTNT TATAVKEKEG KLWCQHEVLC EGFELPRINY DSNGKKVKYV
YGNCVVQSAL ADKIGKFDTE TKKMIYWKED NCWPSEPIFV PRPNGESEDD GVVLAAVINS
NPDQADFLLV LEGRTFTELA RANVNAKLQK DVHGYFIPQ
//
