ID A0A3P8VH37_CYNSE Unreviewed; 485 AA.
AC A0A3P8VH37;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Nuclear factor erythroid 2-related factor 2 {ECO:0000313|Ensembl:ENSCSEP00000011760.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000011760.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000011760.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000011760.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the bZIP family. CNC subfamily.
CC {ECO:0000256|ARBA:ARBA00008157}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008317134.1; XM_008318912.2.
DR RefSeq; XP_016891618.1; XM_017036129.1.
DR STRING; 244447.ENSCSEP00000011756; -.
DR Ensembl; ENSCSET00000011890.1; ENSCSEP00000011749.1; ENSCSEG00000007571.1.
DR Ensembl; ENSCSET00000011897.1; ENSCSEP00000011756.1; ENSCSEG00000007571.1.
DR Ensembl; ENSCSET00000011901.1; ENSCSEP00000011760.1; ENSCSEG00000007571.1.
DR GeneID; 103385131; -.
DR KEGG; csem:103385131; -.
DR CTD; 4778; -.
DR GeneTree; ENSGT00950000182892; -.
DR OMA; LPLRRNC; -.
DR OrthoDB; 382726at2759; -.
DR Proteomes; UP000265120; Chromosome 10.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14720; bZIP_NFE2-like; 1.
DR Gene3D; 1.10.880.10; Transcription factor, Skn-1-like, DNA-binding domain; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR047167; NFE2-like.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR PANTHER; PTHR24411; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR; 1.
DR PANTHER; PTHR24411:SF26; TRANSCRIPTION FACTOR NF-E2 45 KDA SUBUNIT; 1.
DR Pfam; PF03131; bZIP_Maf; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; A DNA-binding domain in eukaryotic transcription factors; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 375..438
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 202..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 400..427
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 313..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 53974 MW; 80471B65EC4EA92D CRC64;
MCSTTNCVLP LRRTCEVLSS PGRVCGGVPM PSNFCGARPH GAPQDTEMDV AWQELMAISE
LQEFNIPGDG SFESTQYQSP ESMVPVGGYG MAQCHLERPS AACNVSSADT FNGCYPEEAA
AAYRPGINLG PTYAHGEYQH NQRSHPTSSQ PTPSLMALRE QMSFARISQG HRRVNTTHSS
QGTYQHGLWT THGQCVRSAD DIESDSGLSL GSSPPLPSPD DPINAVPGYQ GVDVGMTYSD
GEQGLTEHAR RAHIHYSLDH HSSPQSYTDS GAQSNYLAQL TSHTQHSAIQ IKQHNSAAVR
NLYSDSGISS RGSSHLKLYS KPHGSSPSQA PFSRDERRAV ALKIPFPIDK IINLPVDDFN
ELMTQYTLTD TQMALVRDIR RRGKNKVAAQ NCRRRKLEGI FHLEQELNQL QVQKEHLTQE
KLEFQRSLAF VKHRLTDLYT EVFAHLRDEN GQPYSIDEYS LQQTPDGKIY LVPRDYTKER
SMLKN
//
