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Database: UniProt
Entry: A0A3P8VH55_CYNSE
LinkDB: A0A3P8VH55_CYNSE
Original site: A0A3P8VH55_CYNSE 
ID   A0A3P8VH55_CYNSE        Unreviewed;      1531 AA.
AC   A0A3P8VH55;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Adhesion G protein-coupled receptor L2 {ECO:0000313|Ensembl:ENSCSEP00000013682.1};
GN   Name=ADGRL2 {ECO:0000313|Ensembl:ENSCSEP00000013682.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000013682.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000013682.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000013682.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_016898286.1; XM_017042797.1.
DR   Ensembl; ENSCSET00000013842.1; ENSCSEP00000013682.1; ENSCSEG00000008720.1.
DR   GeneTree; ENSGT00940000156348; -.
DR   InParanoid; A0A3P8VH55; -.
DR   Proteomes; UP000265120; Chromosome 2.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd22845; Gal_Rha_Lectin_LPHN2; 1.
DR   Gene3D; 1.25.40.610; -; 1.
DR   Gene3D; 2.60.120.740; -; 1.
DR   Gene3D; 2.60.220.50; -; 1.
DR   Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR046338; GAIN_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR003924; GPCR_2_latrophilin.
DR   InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR000922; Lectin_gal-bd_dom.
DR   InterPro; IPR043159; Lectin_gal-bd_sf.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   PANTHER; PTHR12011:SF61; ADHESION G PROTEIN-COUPLED RECEPTOR L2; 1.
DR   PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF02140; Gal_Lectin; 1.
DR   Pfam; PF01825; GPS; 1.
DR   Pfam; PF02793; HRM; 1.
DR   Pfam; PF02354; Latrophilin; 1.
DR   Pfam; PF02191; OLF; 1.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   PRINTS; PR01444; LATROPHILIN.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00008; HormR; 1.
DR   SMART; SM00284; OLF; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS51132; OLF; 1.
DR   PROSITE; PS50228; SUEL_LECTIN; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..1531
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018220400"
FT   TRANSMEM        860..881
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        893..911
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        923..947
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        959..978
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        998..1021
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1067..1089
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1095..1118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          42..131
FT                   /note="SUEL-type lectin"
FT                   /evidence="ECO:0000259|PROSITE:PS50228"
FT   DOMAIN          141..400
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51132"
FT   DOMAIN          476..533
FT                   /note="G-protein coupled receptors family 2 profile 1"
FT                   /evidence="ECO:0000259|PROSITE:PS50227"
FT   DOMAIN          854..1119
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
FT   REGION          405..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1139..1159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1316..1352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1427..1474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..445
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1427..1447
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        142..324
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ   SEQUENCE   1531 AA;  172318 MW;  9B3FF89A0A88E2F3 CRC64;
     MARSLWNLHT VCWFLLTLTH VHSTEGFSRA ALPFGLVRRE LSCEGYPIDL RCPGSDVIMI
     ESANYGRTDD KICDADPFQM ENINCYLPDA YKIMSQRCNN RTQCIVITGS DVFPDPCPGT
     YKYLEVQYEC VPYKVEQKVF LCPGTLKSVG EPSFVYEAEQ QAGAWCKDPL QAGDKIYFMP
     WTPYRTDTLI EYSSLDDFQN ARQTITYKLP HRVDGTGFVV YDGAVFFNKE RTRNIVKFDL
     RTRIKSGEAI INNANYHDTS PYKWGGKTDI DLAVDENGLW VIYATEHNNG MMVISQLNPY
     TLRFEATWDT AYDKRSASNA FMVCGVLYVV RSTYEDNESE VSKSLIDYVY NTKQNRGEYV
     DIHFPNQYQY IASVDYNPRD NQLYVWNNFY ILRYNLEFGP PDPAHAPPLS EVTSSPPSQR
     TTSTTTTTTT AHRGVANTTA TTGLREGSRG APGAPPLTPH TTSPPPLESF PLPERYCEAA
     ERRDIMWPQT QRGMLVERPC PKGTRGTASY LCVLSTGAWN PRGPDLSNCT SHWVNQVAQK
     IRSGENAANL ANELAKHTKG PIYAGDVSSS VRLMEQLVDI LDAQLQELRP SEKDSAGRSF
     NKLQKRERTC RAYMKAIVDT VDNLLRPEAL KSWRDMNSTE QTHAATMLLD TLEEGAFVLA
     DNLMEPAFVK VPADNIILDV YVLSTDGQVQ DFKFPQSSKS GISIQLSANT VKLNSRNGVA
     KLVFVLYKNL GQFLSTENAT IKMENEAYGR NMSVAVNSDI IAASINKESS RVFINDPVIF
     TLEHIDMEHY FNSNCSFWNY SERSMMGYWS TQGCKLLESN KTHSTCSCSH LTNFAILMAH
     REISVNDRVH ELLLTVITRV GIVVSLVCLT ISIFTFCFFR GLQSDRNTIH KNLCINLFIA
     ELIFLIGIDM TEPRVGCAII AGILHFFFLA SFSWMCLEGV QLYLMLVEVF ESEYSRKKYY
     YVSGYLFPAI VVAVSAAIDY QSYGTKTACW LSVDNHFIWS FIGPVTFVIM LNLIFLVITM
     YKMVKHSTTL KPDSSRLENI NNYRVCDGYY NTDLPGYEDN KRFIKSWVMG AFALLFLLGL
     TWSFGLFFIS EASVVMAYLF TIFNTFQGMF IFVFHCLLQK KVRKEYSKCF RHTSCCGGLP
     TESSHSSAKT STTRTSARYS SGTQSRIRRM WNDTVRKQTE SSFISGDINS TSTLNQGMTG
     NYLLTNPLLR PQGTNNPYNT LLAETVVCNT PTAPVFNSPV TYRETRHSLN KAVRDTSAMD
     TLPLNGNFNN SYSLRNGNFG DSVQVVDCGL SLDDAAFEKM IISELVHNNL RACNKSIQQQ
     QQQQQHHLHH SLHHPPNHQH QQPPQYHHHH HVERAPPKVT VIGGGEDGAI VADASSLARM
     SNTVGLKVHH QQELEAPLIP QRTHSLLYTP QKKVRTDGGV DSFVSQLTPS NPDDSLQSPN
     RDSLYTSMPD LRDSPCAESS PDVVEDVSSS KSESEDIYYK SMPNLGSGHQ LQAYYQIGRG
     GSDGYILPVT KEGCSPEGDV REGQMQLVTS L
//
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