ID A0A3P8VHE8_CYNSE Unreviewed; 485 AA.
AC A0A3P8VHE8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Tubby-like protein {ECO:0000256|RuleBase:RU361125};
GN Name=TULP3 {ECO:0000313|Ensembl:ENSCSEP00000011875.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000011875.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000011875.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000011875.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129,
CC ECO:0000256|RuleBase:RU361125}.
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DR RefSeq; XP_008313848.1; XM_008315626.2.
DR AlphaFoldDB; A0A3P8VHE8; -.
DR STRING; 244447.ENSCSEP00000011875; -.
DR Ensembl; ENSCSET00000012017.1; ENSCSEP00000011875.1; ENSCSEG00000007649.1.
DR GeneID; 103382737; -.
DR KEGG; csem:103382737; -.
DR CTD; 7289; -.
DR GeneTree; ENSGT00940000158155; -.
DR InParanoid; A0A3P8VHE8; -.
DR OMA; FPTYFMH; -.
DR OrthoDB; 603296at2759; -.
DR Proteomes; UP000265120; Chromosome 8.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0036333; P:hepatocyte homeostasis; IEA:Ensembl.
DR GO; GO:0061326; P:renal tubule development; IEA:Ensembl.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR018066; Tubby_C_CS.
DR InterPro; IPR005398; Tubby_N.
DR PANTHER; PTHR16517:SF167; TUBBY-LIKE PROTEIN; 1.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR Pfam; PF01167; Tub; 1.
DR Pfam; PF16322; Tub_N; 2.
DR PRINTS; PR01573; SUPERTUBBY.
DR PRINTS; PR01574; TUBBYPROTEIN.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR PROSITE; PS01200; TUB_1; 1.
DR PROSITE; PS01201; TUB_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 37..91
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 92..218
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 235..480
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 54383 MW; E4AEA0F25AF1CC6F CRC64;
MSYYSIRPSS SASFSSKSTT SGMENDSTNL MQQKLEKQRA LLEQKQRRKR QEPLMVQPNT
EAWPRRSRTR RGEEQAPLVE SQANITNDVI LDGIDGPAAF MSADTSDQGT KVQILSVNQS
HTSPQSQSQS QPQTQPQSPE EPEKDSDTET LLEPKTDIHE LLQKQGLCES MNFDESSGNE
DNVEEEQTRS LSPHADSTRP ASASSGKDVA EVVTPGSPTQ DSSLIDVTNL EEFVLRPAPR
GITIKCRISR DKKGMDRGLY PTYFMHMERE DGKKVFLLAG RKRKKSKTSN YLISVDATDL
SREGDSFIGK LRSNLMGTKF TVYDNGSNPC KNPGALLEES NTRQELAAIC YETNVLGFKG
PRKMTVIIPG MSMNFERVPV RPQSEQESLL SRWQNHSLDN LIELHNKAPV WNDDTQSYVL
NFHGRVTQAS VKNFQIVHDN DPDYIVMQFG RVAEDIFTLD YNYPMCALQA FAIGLSSFDS
KLACE
//
